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2013 | 60 | 3 | 351-360
Article title

NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system

Content
Title variants
Languages of publication
EN
Abstracts
EN
NOD-like proteins (NLR) are a specialized group of intracellular receptors, which constitute an essential component of the host innate immune system. They were discovered more than a decade ago, but research on this particular class of microbial detectors is still ongoing to allow for a better understanding of the mechanisms, recognition of microorganisms, transmission of signals, and carrying out the activation of inflammatory signaling pathways. In this review, we discuss the construction of NOD1 and NOD2 receptors, their functions, and significance in the pathogenesis of inflammatory diseases in humans.
Keywords
EN
NOD1   NOD2   CARD   NF-κB  
Year
Volume
60
Issue
3
Pages
351-360
Physical description
Dates
published
2013
received
2013-04-26
revised
2013-06-28
accepted
2013-07-23
(unknown)
2013-07-31
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Publication order reference
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bwmeta1.element.bwnjournal-article-abpv60p351kz
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