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2013 | 60 | 2 | 259-262
Article title

The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line

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EN
Abstracts
EN
Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).
Publisher

Year
Volume
60
Issue
2
Pages
259-262
Physical description
Dates
published
2013
received
2013-02-11
revised
2013-05-24
accepted
2013-06-03
(unknown)
2013-06-13
Contributors
  • Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland
  • Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland
author
  • Department of Cardiovascular Physiology, Medical University of Lodz, Łódź, Poland
  • Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland
  • Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland
  • Department of Cardiovascular Physiology, Medical University of Lodz, Łódź, Poland
References
  • Amin R, Krammer B, Abdel-Kader N, Verwanger T, El-Ansary A (2010) Antibacterial effect of some benzopyrone derivatives. Eur J Med Chem 45: 372-378.
  • Chiou T, Chu S, Tzeng W (2003) Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation. Toxicology 191: 77-88.
  • Clerkin JS, Naughton R, Quiney C, Cotter TG (2008) Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett 266: 30-36.
  • Di Braccio M, Grossi G, Roma G, Marzano C, Baccichetti F, Simonato M, Bordin F (2003) Pyran derivatives. Part XXI. Antiproliferative and cytotoxic properties of novel N-substituted 4-aminocoumarins, their benzo-fused derivatives, and some related 2-aminochromones. Farmaco 58: 1083-1097.
  • Esterbauer H, Cheeseman KH (1994) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186: 407-413.
  • Gao F, Yao C, Gao E, Mo Q, Yan W, McLaughlin R, Lopez B, Christopher T, Ma X (2002) Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury. J Pharmacol Exp Ther 301: 543-550.
  • Hole PS, Darley RL, Tonks A (2011) Do reactive oxygen species play a role in myeloid leukemias? Blood 117: 5816-5826.
  • Huang W, Ding Y, Miao Y, Liu M, Li Y, Yang G (2009) Synthesis and antitumor activity of novel dithiocarbamate substituted chromones. Eur J Med Chem 44: 3687-3696.
  • Karam M, Lassarre C, Legay C, Ricort J (2012) Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway. Biochim Biophys Acta 1823: 558-569.
  • Kulbacka J, Saczko J, Chwiłkowska A (2009) Oxidative stress in cells damage processes. Pol Merkur Lekarski 27: 44-47 (in Polish).
  • Kulimova E, Oelmann E, Bisping G, Kienast J, Mesters RM, Schwäble J, Hilberg F, Roth GJ, Munzert G, Stefanic M, Steffen B, Brandts C, Müller-Tidow C, Kolkmeyer A, Büchner T, Serve H, Berdel WE (2006) Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived factor and vascular endothelial growth factor receptors. Mol Cancer Ther 5: 3105-3112.
  • Liekens S, Leali D, Neyts J, Esnouf R, Rusnati M, Dell'Era P, Maudgal P, De Clercq E, Presta M (1999) Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds. Mol Pharmacol 56: 204-213.
  • Liu Z, Luo X, Sun Y, Wu W, Liu C, Liu Z, Liu S (2004) The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. J Pharm Pharmacol 56: 1557-1562.
  • Liuzzo JP, Moscatelli D (1996) Human leukemia cell lines bind basic fibroblast growth factor (bFGF) on FGF receptors and heparin sulfates: downmodulation of FGF receptors by phorbol ester. Blood 87: 245-255.
  • Lundin L, Rönnstrand L, Cross M, Hellberg C, Lindahl U, Claesson-Welsh L (2003) Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin. Exp Cell Res 287: 190-198.
  • Łazarenkow A, Nawrot-Modranka J, Brzezińska E, Krajewska U, Różalski M (2012) Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone derivatives of coumarin and chromone. Med Chem Res 21: 1861-1868.
  • Ma Y, Ogino T, Kawabata T, Li J, Eguchi K, Okada S (1999) Cupric nitrilotriacetate-induced apoptosis in HL-60 cells: Association with lipid peroxidation, release of cytochrome C from mitochondria, and activation of caspase-3. Free Radic Biol Med 27: 227-233.
  • Maraldi T, Prata C, Vieceli Dalla Sega F, Caliceti C, Zambonin L, Fiorentini D, Hakim G (2009) NAD(P)H oxidase isoform Nox2 plays a prosurvival role in human leukaemia cells. Free Radic Res 43: 1111-1121.
  • Naughton R, Quiney C, Turner SD, Cotter TG (2009) Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway. Leukemia 23: 1432-1440.
  • Nawrot-Modranka J, Ochocki J, Graczyk J (2004) Phosphorohydrazines of 4-oxo-4H-1-benzopyran and 1-benzopyran-2,4-dione exhibit antitumor activity against L1210 leukemia. Pharmazie 59: 731-732.
  • Nawrot-Modranka J, Nawrot E, Graczyk J (2006) In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazone derivatives of coumarin and chromone. Eur J Med Chem 41: 1301-1309.
  • Nishikawa M (2008) Reactive oxygen species in tumor metastasis. Cancer Lett 266: 53-59.
  • Nunthanavanit P, Anthony NG, Johnston BF, Mackay SP, Ungwitayatorn J (2008) 3D-QSAR studies on chromone derivatives as HIV-1 protease inhibitors: application of molecular field analysis. Arch Pharm (Weinheim) 341: 357-364.
  • Sahni A, Odrljin T, Francis CW (1998) Binding of basic fibroblast growth factor to fibrinogen and fibrin. J Biol Chem 273: 7554-7559.
  • Sallmyr A, Fan J, Datta K, Kim K, Grosu D, Shapiro P, Small D, Rassool F (2008) Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. Blood 111: 3173-3182.
  • Sallmyr A, Fan J, Rassool FV (2008) Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS). DNA double strand breaks (DSBs) and error-prone repair. Cancer Lett 270: 1-9.
  • Singh R, Tripathi A, Tripathi P, Singh S, Singh R, Ahmad R (2009) Studies on biomarkers for oxidative stress in patients with chronic myeloid leukemia. Hematol Oncol Stem Cell Ther 2: 285-288.
  • Ścibior-Bentkowska D, Czeczot H (2009) Cancer cells and oxidative stress. Postepy Hig Med Dosw 63: 58-72.
  • Wang B, Yang Z, Crewdson P, Wang D (2007) Synthesis, crystal structure and DNA-binding studies of the Ln(III) complex with 6-hydroxychromone-3-carbaldehyde benzoyl hydrazone. J Inorg Biochem 101: 1492-1504.
  • Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15: 212-216.
  • Zhou FL, Zhang WG, Wei YC, Meng S, Bai GG, Wang BY, Yang HY, Tian W, Meng X, Zhang H, Chen SP (2010) Involvement of oxidative stress in the relapse of acute myeloid leukemia. J Biol Chem 285: 15010-15015.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv60p259kz
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