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2013 | 60 | 2 | 191-194
Article title

Serum soluble Klotho protein level is associated with residual diuresis in incident peritoneal dialysis patients

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EN
Abstracts
EN
Aim: Active vitamin D (1,25-dihydroxyvitamin D3), PTH, fibroblast growth factor-23 (FGF-23) and Klotho protein are key regulators of phosphate metabolism. Hyperphosphatemia and increased FGF-23 level in patients with end-stage renal disease are associated with increased morbidity and mortality. The relationships among key regulators of phosphate metabolism are still being investigated. FGF-23, the humoral factor involved in phosphate metabolism, is strongly associated with serum phosphorus level. Klotho, a transmembrane protein expressed primarily in renal tubules, functions as an obligatory co-receptor for FGF-23. The soluble form of Klotho, produced by the shedding of the transmembrane protein, is detectable in body fluids. The purpose of the study was to assess if serum soluble alpha-Klotho level was related to phosphate metabolism parameters and residual renal function (RRF) in incident peritoneal dialysis (PD) patients. Methods: Thirty-five clinically stable patients 4 to 6 weeks after the onset of PD were included in the study. For each patient, clinical and laboratory data were reviewed. Serum phosphorus concentration, urinary and peritoneal phosphate clearance, serum FGF-23 and soluble Klotho protein concentrations were determined. Results: Serum soluble alpha-Klotho was strongly negatively correlated with 24-hour diuresis (Rs = -0.55, p = 0.004) and renal phosphate clearance (Rs = -0.40, p = 0.049), but not with RRF. Conclusions: Serum soluble Klotho protein concentration is inversely related to residual diuresis and renal phosphate clearance in incident PD patients.
Publisher

Year
Volume
60
Issue
2
Pages
191-194
Physical description
Dates
published
2013
received
2012-12-30
revised
2013-04-03
accepted
2013-05-23
(unknown)
2013-06-07
Contributors
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
author
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
  • Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
References
  • Akimoto T, Shiizaki K, Sugase T, Watanabe Y, Yoshizawa H, Otani N, Numata A, Takeshima E, Yamazaki T, Miki T, Ito C, Pastor JV, Iwazu Y, Saito O, Muto S, Kuro-o M, Kusano E (2012) The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients. Clin Exp Nephrol 16: 442-447.
  • Cheng CY, Kuro-o M, Razzaque MS (2011) Molecular regulation of phosphate metabolism by Fibroblast Growth Factor-23-Klotho system. Adv Chronic Kidney Dis 18: 91-97.
  • Devaraj S, Syed B, Chien A, Jialal I (2012) Validation of an immunoassay for soluble Klotho protein. Decreased levels in diabetes and increased levels in chronic kidney disease. Am J Clin Pathol 137: 479-485.
  • Drueke TB, Prie D (2007) Klotho spins the thread of life-what does Klotho do to the receptors of fibroblast growth factor-23 (FGF23)? Nephrol Dial Transplant 22: 1524-1526.
  • Hu MC, Kuro-o M, Moe OW (2012) The emerging role of Klotho in clinical nephrology. Nephrol Dial Transplant 27: 2650-2657.
  • Hu MC, Shi M, Zhang J M, Pastor J, Nakatani T, Lanske B, Razzaque MS, Rosenblatt KP, Baum MG, Kuro-o M, Moe OW (2010) Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 24: 3438-3450.
  • Huang CL, Moe OW (2011) Klotho: a novel regulator of calcium and phosphorus homeostasis. Pflugers Arch 462: 185-193.
  • Komaba H, Koizumi M, Tanaka H, Takahashi H, Sawada K, Kakuta T, Fukagawa M (2012) Effects of cinacalcet treatment on serum soluble Klotho levels in haemodialysis patients with secondary hyperparathyroidism. Nephrol Dial Transplant 27: 1967-1969.
  • Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
  • Martin A, David V, Quarles LD (2012) Regulation and function of the FGF23/Klotho endocrine pathways. Physiol Rev 92: 131-155.
  • Razzaque MS (2009) FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player? Am J Physiol Renal Physiol 296: F470-F476.
  • Seiler S, Wen M, Roth HJ, Fehrenz M, Flügge F, Herath E, Weihrauch A, Fliser D, Heine GH (2013) Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease. Kidney Int 83: 121-128.
  • Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L (2011) Plasma Klotho and cardiovascular disease in adults. J Am Geriatr Soc 59: 1596-1601.
  • Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, Inoue M, Fujimoto S, Ikebe M, Yuasa K, Yamanaka S, Terada Y (2012) Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol 16: 722-729.
  • Sugiura H, Tsuchiya K, Nitta K (2011) Circulating levels of soluble α-Klotho in patients with chronic kidney disease. Clin Exp Nephrol 15: 795-796.
  • Torres PU, Prie D, Molina-Bletry V, Beck L, Silve C, Friedlander G (2007) Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 71: 730-737.
  • Wang Y, Sun Z (2009) Current understanding of klotho. Ageing Res Rev 8: 43-51.
  • Yokoyama KK, Imura AA, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, Urae J, Sekino H, Nabeshima Y, Hosoya T (2012) Serum soluble α-Klotho in hemodialysis patients. Clin Nephrol 77: 347-351.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv60p191kz
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