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2013 | 60 | 2 | 183-189
Article title

Detection of selective antibacterial peptides by the Polarity Profile method

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EN
Abstracts
EN
Antimicrobial peptides occupy a prominent place in the production of pharmaceuticals, because of their effective contribution to the protection of the immune system against almost all types of pathogens. These peptides are thoroughly studied by computational methods designed to shed light on their main functions. In this paper, we propose a computational approach, named the Polarity Profile method that represents an improvement to the former Polarity Index method. The Polarity Profile method is very effective in detecting the subgroup of antibacterial peptides called selective cationic amphipathic antibacterial peptides (SCAAP) that show high toxicity towards bacterial membranes and exhibit almost zero toxicity towards mammalian cells. Our study was restricted to the peptides listed in the antimicrobial peptides database (APD2) of December 19, 2012. Performance of the Polarity Profile method is demonstrated through a comparison to the former Polarity Index method by using the same sets of peptides. The efficiency of the Polarity Profile method exceeds 85% taking into account the false positive and/or false negative peptides.
Publisher

Year
Volume
60
Issue
2
Pages
183-189
Physical description
Dates
published
2013
received
2012-12-27
revised
2013-04-25
accepted
2013-05-14
(unknown)
2013-06-06
Contributors
  • Facultad de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan Estado de México, México
author
  • Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca Morelos, México
  • Facultad de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan Estado de México, México
  • Facultad de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan Estado de México, México
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv60p183kz
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