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2013 | 60 | 2 | 167-173
Article title

Low-glucose medium induces ORP150 expression and exerts inhibitory effect on apoptosis and senescence of human breast MCF7 cells

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EN
Abstracts
EN
Glucose deprivation is a factor evoking endoplasmic reticulum (ER) stress and induction of expression of an oxygen-regulated protein of 150 kDa (ORP150). We studied the effect of inducible overexpression of ORP150 on senescence and apoptosis of human breast carcinoma cells (MCF7) and human skin fibroblasts. We found an inhibitory effect of ORP150 on apoptosis and senescence of MCF7 cells, but not fibroblasts in ER stress conditions. An increased expression of senescence-associated β-galactosidase and acid β-galactosidase activity (biomarkers of cellular senescence) was observed. We suggest that ORP150 induction in cancer cells can promote tumour progression and may be a major cause of their resistance to chemotherapeutics.
Keywords
Publisher

Year
Volume
60
Issue
2
Pages
167-173
Physical description
Dates
published
2013
received
2012-12-10
revised
2013-04-29
accepted
2013-06-05
(unknown)
2013-06-12
Contributors
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Bialystok, Poland
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Bialystok, Poland
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Bialystok, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv60p167kz
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