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2012 | 59 | 4 | 599-601
Article title

Trace elements and rat pouchitis

Content
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EN
Abstracts
EN
The procedure of restorative proctocolectomy is associated with a complete removal of the colon and slight reduction of ileum length, which together can lead to systemic shortages of trace elements. Inflammatory changes in the pouch mucosa may also have some impact. However, there is no data on trace elements in pouchitis. Therefore, in the present study we aimed to assess the effect of acute pouchitis on the status of selected trace elements in rats. Restorative proctocolectomy with the construction of intestinal J-pouch was performed in twenty-four Wistar rats. Three weeks after the surgery, pouchitis was induced. Eight untreated rats created the control group. Liver concentrations of selected micronutrients (Zn, Cu, Co, Mn, Se) were measured in both groups six weeks later, using inductively coupled plasma mass spectrometry. Liver concentrations of trace elements did not differ between the study and the control groups. However, copper, cobalt and selenium concentrations [μg/g] were statistically lower (p<0.02, p<0.05 and p<0.04, respectively) in rats with severe pouchitis (n=9) as compared with rats with mild pouchitis (n=7) [median (range): Cu - 7.05 (3.02-14.57) vs 10.47 (5.16-14.97); Co - 0.55 (0.37-0.96) vs 0.61 (0.52-0.86); Se - 1.17 (0.69-1.54) vs 1.18 (0.29-1.91)]. In conclusion, it seems that acute pouchitis can lead to a significant deficiency of trace elements.
Publisher

Year
Volume
59
Issue
4
Pages
599-601
Physical description
Dates
published
2012
received
2012-04-20
revised
2012-10-24
accepted
2012-11-23
(unknown)
2012-11-30
Contributors
  • Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poznań, Poland
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Kraków, Poland
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
  • I Chair of Pediatrics, Department of Pediatric Gastroenterology and Metabolism, Poznań University of Medical Sciences, Poznań, Poland
author
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poznań, Poland
References
  • Arjona A, Mata M, Bonet M (1997) Diagnosis of chronic manganese intoxication by magnetic resonance imaging. N Engl J Med 336: 964-965.
  • Babu M, Purhonen AK, Bansiewicz T, Mäkelä K, Walkowiak J, Miettinen P, Herzig KH (2005) Effect of total colectomy and PYY infusion on food intake and body weight in rats. Regul Pept 131: 29-33.
  • Berdanier CD (2004) Trace Minerals. In Advanced Nutrition: Micronutrients. pp 184-215. CRP Press, New York.
  • Bertinet DB, Tinivella M, Balzola FA, de Francesco A, Davini O, Rizzo L, Massarenti P, Leonardi MA, Balzola F (2000) Brain manganese deposition and blood levels in patients undergoing home parenteral nutrition. J Parenter Enteral Nutr 24: 223-227.
  • Drzymała-Czyż S, Banasiewicz T, Tubacka M, Tarasiuk-Rusek A, Majewski P, Drews M, Walkowiak J (2012) Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. Folia Histochem Cytobiol 50: 125-129.
  • El Muhtaseb MS, Duncan A, Talwar DK, O'Reilly DS, McKee RF, Anderson JH, Finlay IG (2007) Assessment of dietary intake and trace element status in patients with ileal pouch-anal anastomosis. Dis Colon Rectum 50: 1553-1557.
  • Kuisma J, Nuutinen H, Luukkonen P, Järvinen H, Kahri A, Färkkilä M (2001) Long term metabolic consequences of ileal pouch-anal anastomosis for ulcerative colitis. Am J Gastroenterol 96: 3110-3106.
  • M'Koma AE, Lindquist K, Liljeqvist L (1994) Biochemical laboratory data in patients before and after restorative proctocolectomy. A study on 83 patients with a follow-up of 36 months. Ann Chir 48: 525-534.
  • Olivares JA (1998) Inductively coupled plasma-mass spectrometry. Methods Enzymol 158: 205-222.
  • Pastrana RJ, Torres EA, Arroyo JM, Rivera CE, Sánchez CJ, Morales L (2007) Iron-deficiency anemia as presentation of pouchitis. J Clin Gastroenterol 41: 41-44.
  • Pironi L, Miglioli M, Ruggeri E, Dallasta MA, Poggioli G, Caudarella R, Piazzi S, Miniero R, Gozzetti G, Barbara L (1991) Nutritional status of patients undergoing ileal pouch-anal anastomosis. Clin Nutr 10: 292-297.
  • Ringstad J, Kildebo S, Thomassen Y (1993) Serum selenium, copper, and zinc concentrations in Crohn's disease and ulcerative colitis. Scand J Gastroenterol 28: 605-608.
  • Sandborn WJ, Tremaine WJ, Batts KP, Pemberton JH, Phillips SF (1994) Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index. Mayo Clin Proc 69: 409-415.
  • Sandström B (2001) Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 85: S181-S185.
  • Serra-Majem L, Pfrimer K, Doreste-Alonso J, Ribas-Barba L, Sánchez-Villegas A, Ortiz-Andrellucchi A, Henríquez-Sánchez P (2009) Dietary assessment methods for intakes of iron, calcium, selenium, zinc and iodine. Br J Nutr 102: S38-55.
  • Vagianos K, Bector S, McConnell J, Bernstein CN (2007) Nutrition assessment of patients with inflammatory bowel disease. J Parenter Enteral Nutr 31: 311-319.
  • Yu ED, Shao Z, Shen B (2007) Pouchitis. World J Gastroenterol 13: 5598-5604.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv59p599kz
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