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2012 | 59 | 4 | 575-580
Article title

Some heterocyclic thione derivatives exhibit anticoccidial activity by inhibiting glycosidases

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Abstracts
EN
Coccidiosis is one of the most common parasitic diseases affecting many species of domestic animals. This disease has a major economic significance and the search for new compounds having anticoccidial activity is of great importance. In this article, different levels of protection from coccidian infection by Eimeria stiedae were developed in rabbits by treatment with compounds incorporating the skeleton of thiourea. These compounds include 4,5-diphenylimidazole-2-thione (1), 4,5-Diphenyl-1,2,4-triazole-3-thiol (2) and 5-(2-Hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thiol (3) compared to the anticoccidial drug toltrazuril as a reference compound. Compounds 1-3 inhibit coccidiosis-induced activity of α-glucosidase. The protection from coccidial infection by compound 1 was higher than that shown for compounds 2 and 3. These data suggest that diazole and triazole thione derivatives have a mimetic effect for anticoccidial drugs through their inhibition of glycosidases.
Publisher

Year
Volume
59
Issue
4
Pages
575-580
Physical description
Dates
published
2012
received
2012-02-12
revised
2012-06-10
accepted
2012-08-22
(unknown)
2012-10-16
Contributors
  • Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
  • Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
author
  • Biochemistry Department, Edfina Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt
  • Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv59p575kz
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