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2012 | 59 | 4 | 475-482
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Pro-inflammatory properties of cadmium

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Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem. The aim of this study is to review the effects of cadmium on selected inflammatory mediators and markers, such as NF-κB and AP-1 transcription factors, IL-6, TNF-α, IL-1β cytokines, IL-8 or MIP-2 chemokine, MPO, iNOS, MMPs and COX-2 enzymes, PGE2 (product of COX-2 enzyme), ICAM-1, VCAM-1 and PECAM-1 adhesion molecules, and CRP. The research strategy identified articles available in Medline, published between 1998 and 2012; we included both in vivo and in vitro studies carried out on humans and rodents. Most of the reviewed research findings suggest that cadmium in micromolar concentrations (especially in the 1-10 μM range) causes up-regulation of the mediators and markers of inflammation, and appears to have pro-inflammatory properties. However, it is worth mentioning that a contradictory or even opposite hypothesis exists, which suggests cadmium to be an anti-inflammatory factor. Further research including detailed histological analyses should solve this discrepancy. Nevertheless, it appears that the main reason for these contradictory findings is the experimental setup: different biological systems analyzed and different doses of cadmium applied.
Physical description
  • Department of Hygiene, Epidemiology and Public Health, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland
  • Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
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