Inhibitors of N-glycosylation as a potential tool for analysis of the mechanism of action and cellular localisation of glycoprotein P

• Authors: Karolina Wojtowicz , Witold Szaflarski , Radosław Januchowski , Piotr Zawierucha , Michał Nowicki , Maciej Zabel
• Languages of publication: EN

Abstracts

EN

Multidrug resistance has for many years attracted attention of numerous investigators. Attempts have also been made to increase efficiency of anti-neoplastic therapy. For this reason, most of efforts have been devoted to analysing proteins engaged in the mechanism of multidrug resistance such as the N-glycosylated membrane protein glycoprotein P. Interestingly, glycosylation probably plays a significant role in the intracellular location and activity of modified proteins. Inhibitors of glycosylation have been demonstrated to alter the activity of glycoprotein P in various ways, depending on the cell line examined. These inhibitors markedly reduce multidrug resistance of cancer cells, thus promoting success of anti-neoplastic therapy. Here, we review the basic knowledge on N-glycosylation inhibitors, their effect on glycoprotein P and their therapeutic potential.

Keywords

EN

N-glycosylation; glycoprotein P; multidrug resistance; inhibitors

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2012
• Volume: 59
• Issue: 4
• Pages: 445-450

Dates

published

2012

received

2012-05-18

revised

2012-09-21

accepted

2012-10-16

(unknown)

2012-10-23

Contributors

author

Karolina Wojtowicz

• Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland

author

Witold Szaflarski

• Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland

author

Radosław Januchowski

• Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland

author

Piotr Zawierucha

• Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland

author

Michał Nowicki

• Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland

author

Maciej Zabel

• Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland

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