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2012 | 59 | 4 | 445-450
Article title

Inhibitors of N-glycosylation as a potential tool for analysis of the mechanism of action and cellular localisation of glycoprotein P

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Multidrug resistance has for many years attracted attention of numerous investigators. Attempts have also been made to increase efficiency of anti-neoplastic therapy. For this reason, most of efforts have been devoted to analysing proteins engaged in the mechanism of multidrug resistance such as the N-glycosylated membrane protein glycoprotein P. Interestingly, glycosylation probably plays a significant role in the intracellular location and activity of modified proteins. Inhibitors of glycosylation have been demonstrated to alter the activity of glycoprotein P in various ways, depending on the cell line examined. These inhibitors markedly reduce multidrug resistance of cancer cells, thus promoting success of anti-neoplastic therapy. Here, we review the basic knowledge on N-glycosylation inhibitors, their effect on glycoprotein P and their therapeutic potential.
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  • Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland
  • Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland
  • Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland
  • Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland
  • Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland
  • Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland
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