Bacterial putative metacaspase structure from Geobacter sulfureducens as a template for homology modeling of type II Triticum aestivum metacaspase (TaeMCAII)

• Authors: Malgorzata Z. Dudkiewicz , Ewa Piszczek
• Languages of publication: EN

Abstracts

EN

Metacaspases, cysteine proteases belonging to the peptidase C14 family, are suspected of being involved in the programmed cell death of plants, although their sequences and substrate specificity differ from those of animal caspases. At present, the knowledge on the metacaspase reaction mechanism is based only on biochemical data and homology models constructed on caspase templates. Here we propose a novel template for metacaspase modeling and demonstrate important advantages in comparison to the conventionally used caspase templates. We also point out the connection between plant and bacterial metacaspases, underlining the prokaryotic roots of Programmed Cell Death (PCD).

Keywords

EN

Programmed Cell Death; metacaspase

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2012
• Volume: 59
• Issue: 3
• Pages: 401-406

Dates

published

2012

received

2012-04-10

accepted

2012-06-27

revised

2012-08-24

(unknown)

2012-08-27

Contributors

author

Malgorzata Z. Dudkiewicz

• Department of Biometrics and Bioinformatics, Warsaw University of Life Sciences - SGGW, Warsaw, Poland

author

Ewa Piszczek

• Department of Biochemistry, Faculty of Agriculture and Biology, Warsaw University of Life Sciences - SGGW, Warsaw, Poland

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