Modulation of the human preadipocyte mitochondrial activity by beta-carotene

• Authors: Agnieszka Śliwa , Joanna Góralska , Urszula Czech , Anna Gruca , Anna Polus , Barbara Zapała , Aldona Dembińska-Kieć
• Languages of publication: EN

Abstracts

EN

Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria.

Keywords

EN

oxidative phosphorylation; preadipocytes; mitochondria; beta-carotene

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2012
• Volume: 59
• Issue: 1
• Pages: 39-41

Dates

published

2012

received

2011-10-14

accepted

2012-03-01

(unknown)

2012-03-17

Contributors

author

Agnieszka Śliwa

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

author

Joanna Góralska

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

author

Urszula Czech

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

author

Anna Gruca

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

author

Anna Polus

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

author

Barbara Zapała

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

author

Aldona Dembińska-Kieć

• Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland

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