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2012 | 59 | 1 | 39-41
Article title

Modulation of the human preadipocyte mitochondrial activity by beta-carotene

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EN
Abstracts
EN
Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria.
Year
Volume
59
Issue
1
Pages
39-41
Physical description
Dates
published
2012
received
2011-10-14
accepted
2012-03-01
(unknown)
2012-03-17
Contributors
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
author
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
author
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
author
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
  • Department of Clinical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv59p39kz
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