Correlation between butyrylcholinesterase variants and sensitivity to soman toxicity

• Authors: Dimo Dimov , Kamen Kanev , Ivanka Dimova
• Languages of publication: EN

Abstracts

EN

Butyrylcholinesterase (BChE) is synthesized in the liver and found in high concentrations in blood plasma, liver, heart, pancreas, vascular endothelium, skin, brain white matter, smooth muscle cells and adipocytes. BChE is a non specific enzyme that hydrolyzes different choline esters (succinylcholine, mivacurium) and many other drugs such as aspirin, cocaine and procaine. The enzyme is also considered as a bioscavenger due to its ability to neutralize the toxic effects of organophosphorus compounds (nervous system fs agents) such as soman. BChE displays several polymorphisms that influence its serum activity; therefore they could determine the individual sensitivity to chemical nerve agents. In this study, we investigated the correlation between BChE variants and the degree of enzyme inhibition and reactivation after soman application on blood samples of 726 individuals. The blood samples of individuals expressing abnormal variants, were more sensitive to soman compared to variants of homozygotes and heterozygotes for U-allele. We found significant differences in the degree of enzyme reactivation between different variants (with and without U-presence).

Keywords

EN

enzyme inhibition/reactivation; soman toxicity; Butyrylcholinesterase variants

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2012
• Volume: 59
• Issue: 2
• Pages: 313-316

Dates

published

2012

received

2012-02-12

revised

2012-04-04

accepted

2012-05-18

(unknown)

2012-06-13

Contributors

author

Dimo Dimov

• Disaster Medicine and Toxicology Deparment, Military Medical Academy, Sofia, Bulgaria

author

Kamen Kanev

• Disaster Medicine and Toxicology Deparment, Military Medical Academy, Sofia, Bulgaria

author

Ivanka Dimova

• Department of Medical Genetics, Medical University, Sofia, Bulgaria

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