Interactions of dietary carotenoids with singlet oxygen (1O2) and free radicals: potential effects for human health

• Authors: Fritz Böhm , Ruth Edge , T George Truscott
• Languages of publication: EN

Abstracts

EN

The dietary carotenoids provide photoprotection to photosynthetic organisms, the eye and the skin. The protection mechanisms involve both quenching of singlet oxygen and of damaging free radicals. The mechanisms for singlet oxygen quenching and protection against free radicals are quite different - indeed, under some conditions, quenching of free radicals can lead to a switch from a beneficial anti-oxidant process to damaging pro-oxidative situation. Furthermore, while skin protection involves β-carotene or lycopene from a tomato-rich diet, protection of the macula involves the hydroxyl-carotenoids (xanthophylls) zeaxanthin and lutein. Time resolved studies of singlet oxygen and free radicals and their interaction with carotenoids via pulsed laser and fast electron spectroscopy (pulse radiolysis) and the possible involvement of amino acids are discussed and used to (1) speculate on the anti- and pro-oxidative mechanisms, (2) determine the most efficient singlet oxygen quencher and (3) demonstrate the benefits to photoprotection of the eye from the xanthophylls rather than from hydrocarbon carotenoids such as β-carotene.

Keywords

EN

dietary carotenoids; singlet oxygen; free radicals; redox potentials

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2012
• Volume: 59
• Issue: 1
• Pages: 27-30

Dates

published

2012

received

2011-11-19

accepted

2012-03-01

(unknown)

2012-03-17

Contributors

author

Fritz Böhm

• Department of Dermatology, Charité-Universitätsmedizin, Berlin, Germany

author

Ruth Edge

• Dalton Cumbrian Facility, The University of Manchester, Westlakes Science and Technology Park, Cumbria, UK

author

T George Truscott

• School of Physical and Geographical Sciences (Chemistry Section), Keele University, Keele, Staffordshire, UK

References

• Bensasson RV, Land EJ, Truscott TG (1993) Excited States and Free Radicals in Biology and Medicine. p 195. Oxford University Press, Oxford.
• Bisby RH, Parker AW (1995) Reaction of ascorbate with the α-tocopheroxyl radical in micellar and bilayer membrane systems. Arch Biochem Biophys 317: 170-178.
• Burke M, Edge R, Land EJ, Truscott TG (2001) Characterisation of carotenoid radical cations in liposomal environments: interaction with vitamin C. J Photochem Photobiol B 60: 1-6.
• Cantrell A, McGarvey DJ, Truscott TG, Rancan F, Böhm F (2003) Singlet oxygen quenching by dietary carotenoids in a model membrane environment. Arch Biochem Biophys 412: 47-54.
• Edge R, Truscott TG (2010) Properties of carotenoid radicals and excited states and their potential role in biological systems. In Carotenoids: Physical, chemical and biological functions and properties. Landrum JT, ed, pp 283-304. CRC Press, Boca Raton.
• Edge R, Land EJ, McGarvey D, Mulroy L, Truscott TG (1998) Relative one-electron reduction potentials of carotenoid radical cations and the interactions of carotenoids with the vitamin E radical cation. J Am Chem Soc 120: 4087-4090.
• Edge R, McGarvey D, Truscott TG (1997) The carotenoids as anti-oxidants. J Photochem Photobiol B: Biol 41: 189-200.
• Gouranton E, Yazidi CL, Cardinault N, Amiot MJ, Borel P, Landrier JF (2008) Purified low-density lipoprotein and bovine serum albumin efficiency to internalise lycopene into adipocytes, Food Chem Toxicol 46: 3832-3836.
• Harriman A (1987) Further comments on the redox potentials of tryptophan and tyrosine. J Phys Chem 91: 6102-6104.
• Mares-Pearlman JA, Bracy WE, Klein R (1995) Serum antioxidants and age-related macular degeneration in a population controlled study. Arch Ophthalmol 113: 1518-1523.
• Packer JE, Slater TF, Willson RL (1979) Direct observation of a free radical interaction between Vitamin E and vitamin C. Nature 278: 737-738.
• The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New Engl J Med 330: 1029-1035.