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2012 | 59 | 1 | 27-30
Article title

Interactions of dietary carotenoids with singlet oxygen (1O2) and free radicals: potential effects for human health

Content
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Languages of publication
EN
Abstracts
EN
The dietary carotenoids provide photoprotection to photosynthetic organisms, the eye and the skin. The protection mechanisms involve both quenching of singlet oxygen and of damaging free radicals. The mechanisms for singlet oxygen quenching and protection against free radicals are quite different - indeed, under some conditions, quenching of free radicals can lead to a switch from a beneficial anti-oxidant process to damaging pro-oxidative situation. Furthermore, while skin protection involves β-carotene or lycopene from a tomato-rich diet, protection of the macula involves the hydroxyl-carotenoids (xanthophylls) zeaxanthin and lutein. Time resolved studies of singlet oxygen and free radicals and their interaction with carotenoids via pulsed laser and fast electron spectroscopy (pulse radiolysis) and the possible involvement of amino acids are discussed and used to (1) speculate on the anti- and pro-oxidative mechanisms, (2) determine the most efficient singlet oxygen quencher and (3) demonstrate the benefits to photoprotection of the eye from the xanthophylls rather than from hydrocarbon carotenoids such as β-carotene.
Publisher

Year
Volume
59
Issue
1
Pages
27-30
Physical description
Dates
published
2012
received
2011-11-19
accepted
2012-03-01
(unknown)
2012-03-17
Contributors
author
  • Department of Dermatology, Charité-Universitätsmedizin, Berlin, Germany
author
  • Dalton Cumbrian Facility, The University of Manchester, Westlakes Science and Technology Park, Cumbria, UK
  • School of Physical and Geographical Sciences (Chemistry Section), Keele University, Keele, Staffordshire, UK
References
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  • Edge R, Truscott TG (2010) Properties of carotenoid radicals and excited states and their potential role in biological systems. In Carotenoids: Physical, chemical and biological functions and properties. Landrum JT, ed, pp 283-304. CRC Press, Boca Raton.
  • Edge R, Land EJ, McGarvey D, Mulroy L, Truscott TG (1998) Relative one-electron reduction potentials of carotenoid radical cations and the interactions of carotenoids with the vitamin E radical cation. J Am Chem Soc 120: 4087-4090.
  • Edge R, McGarvey D, Truscott TG (1997) The carotenoids as anti-oxidants. J Photochem Photobiol B: Biol 41: 189-200.
  • Gouranton E, Yazidi CL, Cardinault N, Amiot MJ, Borel P, Landrier JF (2008) Purified low-density lipoprotein and bovine serum albumin efficiency to internalise lycopene into adipocytes, Food Chem Toxicol 46: 3832-3836.
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  • The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New Engl J Med 330: 1029-1035.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv59p27kz
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