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2012 | 59 | 2 | 255-260
Article title

Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage

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Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of α-amyrin indicated no antioxidative activity of this compound. α-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.
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  • Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
  • Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, Poland
  • Department of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
  • Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, Poland
  • Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
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