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2012 | 59 | 1 | 167-169
Article title

Comparison of dietary supplementation with lutein diacetate and lutein: a pilot study of the effects on serum and macular pigment

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EN
Abstracts
EN
The responses of subjects taking a 20 mg/day lutein diacetate supplement were compared with that for a 20 mg/day crystalline lutein or a placebo. Ten subjects, assigned to each of three groups, lutein diacetate (group 1), lutein (group 2), and a placebo (group 3), were supplemented for 24 weeks. Groups 1 and 2 consumed a dose equivalent to 20 mg per day of free lutein. Serum samples, collected at baseline, and at weeks 6, 12, 18, and 24 were analyzed by HPLC. Macular Pigment Optical Density (MPOD) was obtained by heterochromatic flicker photometry at baseline and weeks 6, 12, 18 and 24. Results: The average serum lutein concentrations for weeks 6 to 24 expressed as a ratio to the baseline value (±S.D.) were 5.52±2.88 for group 1, 4.43±1.61 for group 2, and 1.03±0.25 for group 3. The median rate of macular pigment increase (milli-absorbance units/week) for groups 1, 2, and 3 were 2.35, 1.55, and 0.19 mAU/wk, respectively. P-values for these serum and MPOD increases are both highly significant when compared to placebo. The average serum response was about 25% higher for group 1 compared with group 2 and, the median MPOD response was 52% higher for group 1 than group 2. P-values calculated for the differences in these increases were, p = 0.066, marginally significant, for serum, and p = 0.09 approaching significance, for MPOD.
Publisher

Year
Volume
59
Issue
1
Pages
167-169
Physical description
Dates
published
2012
received
2011-10-17
accepted
2012-03-01
(unknown)
2012-03-17
Contributors
author
  • Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA
author
  • Department of Physics, Florida International University, Miami, FL, USA
author
  • Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA
  • Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA
author
  • Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA
References
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  • Roodenburg AJC, Leenen R, van het Hof KH, Weststrate JA, Tijburg LBM (2000) Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Am J Clin Nutr 71: 1187-1193.
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv59p167kz
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