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2012 | 59 | 1 | 149-150
Article title

Synthesis of carotenoid-cysteine conjugates

Content
Title variants
Languages of publication
EN
Abstracts
EN
Isozeaxanthin under acidic conditions forms an allylic cation which reacts readily with thiol nucleophiles. With N-acetylcysteine as a nucleophile the products obtained are carotenoid-cysteine conjugates in which the amino acid moiety is attached to the carotenoid via sulphur in position 4. The water solubility of the products can be increased by deprotection of the amino group. The antioxidant activity of the products were examined on human liver cells under conditions of hydrogen-peroxide induced oxidative stress.
Publisher

Year
Volume
59
Issue
1
Pages
149-150
Physical description
Dates
published
2012
received
2011-10-17
accepted
2012-03-01
(unknown)
2012-03-17
Contributors
author
  • Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary
author
  • Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary
author
  • Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary
author
  • Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary
References
  • Deli J, Agócs A, Iványi R, Németh K, Visy J, Szemán J, Szente L, Simonyi M (2008) Preparation and characterization of water soluble carotenoid/cyclodextrin complexes. Carotenoid Sci 12: 201.
  • Háda M, Petrovics D, Nagy V, Böddi K, Deli J, Agócs A (2011) The first synthesis of PEG-carotenoid conjugates. Tetrahedron Lett 52: 3195-3197.
  • Lutneas BJ, Kildahl-Andersen G, Krane J, Liaaen-Jensen S (2004) Delocalized carotenoid cations in relation to the soliton model. J Am Chem Soc 126: 8981-8990.
  • Nagy V, Agócs A, Turcsi E, Deli J (2010) Experiments on the synthesis of carotenoid glycosides. Tetrahedron Lett 51: 2020-2022.
  • Socaciu C, Lausch C, Diehl HA (1999) Carotenoids in DPPC vesicles: membrane dynamics. Spectrochim Acta Part A 55: 2289-2297.
  • Tapodi A, Debreceni B, Hantó K, Bognár Z, Wittmann I, Gallyas F, Várbíró G, Sümegi B (2005) Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose) polymerase-1 inhibition in oxidative stress. J Biol Chem 280: 35767-35775.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv59p149kz
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