Vitamin K status in peritoneally dialyzed patients with chronic kidney disease

• Authors: Hanna Stankowiak-Kulpa , Patrycja Krzyżanowska , Lidia Kozioł , Marian Grzymisławski , Maria Wanic-Kossowska , Jerzy Moczko , Jarosław Walkowiak
• Languages of publication: EN

Abstracts

EN

Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory. Therefore, in the present study we aimed to evaluate vitamin K status in patients with CKD who are treated with continuous ambulatory PD. Twenty-eight patients entered into the study. Dialysis vintage ranged from 3 to 89 months. Vitamin K status was assessed in all subjects using undercarboxylated prothrombin measurement (PIVKA-II). In addition, total protein and albumin levels, total cholesterol, LDL cholesterol, triglyceride, calcium, urea and creatinine concentrations were determined. PIVKA-II concentrations were abnormal in 13 (46.4 %) subjects. BMI values, both total and LDL cholesterol concentrations were significantly higher in patients with than those without vitamin K deficiency. Moreover, PIVKA II levels correlated with BMI values (r = 0.441, p < 0.019), LDL cholesterol (r = 0.434, p < 0.021) and creatinine (r = 0.406, p < 0.032) concentrations. However, through the use of logistic regression analysis and multiple regression analysis, no clinical factor was documented to be the independent risk factor of vitamin K deficiency. In conclusion, vitamin K deficiency is a frequent condition in peritoneally dialyzed patients. Assessment of vitamin K status should become a standard procedure in this group of patients.

Keywords

EN

dialysis; vitamin K; kidney disease

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2011
• Volume: 58
• Issue: 4
• Pages: 617-620

Dates

published

2011

received

2011-07-29

revised

2011-11-17

accepted

2011-12-16

(unknown)

2011-12-20

Contributors

author

Hanna Stankowiak-Kulpa

• Department of Internal Medicine, Metabolism and Dietetics, Poznań University of Medical Sciences, Poznań, Poland

author

Patrycja Krzyżanowska

• Department of Pediatric Gastroenterology and Metabolism, Poznań University of Medcial Sciences, Poznań, Poland

author

Lidia Kozioł

• Department of Nephrology and Transplantology, Poznań University of Medical Sciences, Poznań, Poland

author

Marian Grzymisławski

• Department of Internal Medicine, Metabolism and Dietetics, Poznań University of Medical Sciences, Poznań, Poland

author

Maria Wanic-Kossowska

• Department of Nephrology and Transplantology, Poznań University of Medical Sciences, Poznań, Poland

author

Jerzy Moczko

• Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań, Poland

author

Jarosław Walkowiak

• Department of Pediatric Gastroenterology and Metabolism, Poznań University of Medcial Sciences, Poznań, Poland

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