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2011 | 58 | 4 | 617-620
Article title

Vitamin K status in peritoneally dialyzed patients with chronic kidney disease

Content
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EN
Abstracts
EN
Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory. Therefore, in the present study we aimed to evaluate vitamin K status in patients with CKD who are treated with continuous ambulatory PD. Twenty-eight patients entered into the study. Dialysis vintage ranged from 3 to 89 months. Vitamin K status was assessed in all subjects using undercarboxylated prothrombin measurement (PIVKA-II). In addition, total protein and albumin levels, total cholesterol, LDL cholesterol, triglyceride, calcium, urea and creatinine concentrations were determined. PIVKA-II concentrations were abnormal in 13 (46.4 %) subjects. BMI values, both total and LDL cholesterol concentrations were significantly higher in patients with than those without vitamin K deficiency. Moreover, PIVKA II levels correlated with BMI values (r = 0.441, p < 0.019), LDL cholesterol (r = 0.434, p < 0.021) and creatinine (r = 0.406, p < 0.032) concentrations. However, through the use of logistic regression analysis and multiple regression analysis, no clinical factor was documented to be the independent risk factor of vitamin K deficiency. In conclusion, vitamin K deficiency is a frequent condition in peritoneally dialyzed patients. Assessment of vitamin K status should become a standard procedure in this group of patients.
Keywords
Publisher

Year
Volume
58
Issue
4
Pages
617-620
Physical description
Dates
published
2011
received
2011-07-29
revised
2011-11-17
accepted
2011-12-16
(unknown)
2011-12-20
Contributors
  • Department of Internal Medicine, Metabolism and Dietetics, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Pediatric Gastroenterology and Metabolism, Poznań University of Medcial Sciences, Poznań, Poland
author
  • Department of Nephrology and Transplantology, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Internal Medicine, Metabolism and Dietetics, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Nephrology and Transplantology, Poznań University of Medical Sciences, Poznań, Poland
author
  • Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Pediatric Gastroenterology and Metabolism, Poznań University of Medcial Sciences, Poznań, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv58p617kz
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