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2011 | 58 | 4 | 477-488
Article title

Indirect inactivation of tyrosinase in its action on tyrosine

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Abstracts
EN
Under aerobic conditions, tyrosinase is inactivated by dopa as a result of suicide inactivation, and, under anaerobic conditions, as a result of irreversible inactivation. However, tyrosine protects the enzyme from being inactivated by dopa under anaerobic conditions. This paper describes how under aerobic conditions the enzyme acting on tyrosine is not directly inactivated but undergoes a process of indirect suicide inactivation provoked by reaction with the o-diphenol originated from the evolution of o-dopaquinone and accumulated in the reaction medium.
Keywords
Publisher

Year
Volume
58
Issue
4
Pages
477-488
Physical description
Dates
published
2011
received
2010-12-09
revised
2011-11-09
accepted
2011-12-02
(unknown)
2011-12-20
Contributors
  • GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia, Espinardo, Murcia, Spain
  • GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia, Espinardo, Murcia, Spain
  • GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia, Espinardo, Murcia, Spain
  • Departamento de Física Aplicada, Escuela Politécnica Superior de Albacete, Universidad de Castilla la Mancha, Albacete, Spain
  • QCBA: Grupo de Química de Carbohidratos y Biotecnología de Alimentos, Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Espinardo, Murcia, Spain
author
  • GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia, Espinardo, Murcia, Spain
  • GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia, Espinardo, Murcia, Spain
  • GENZ: Grupo de Investigación Enzimología, Departamento de Bioquímica y Biología Molecular-A, Facultad de Biología, Universidad de Murcia, Espinardo, Murcia, Spain
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv58p477kz
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