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2011 | 58 | 3 | 385-389
Article title

A levels of endogenous gonadal hormones and their relationship with selected coronary artery disease risk factors among young women post myocardial infarction

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Abstracts
EN
In recent decades a significant raise in the incidence of myocardial infarction among young women has been recorded. It is presumed that, apart from the classical risk factors, other reasons exist for premature atherosclerosis in young women, related to the homeostasis of gonadal hormones. The aim of the study was to analyze the levels of gonadal hormones (estradiol, progesterone, follicle-stimulating hormone, luteinizing hormone, testosterone and dehydroepiandrosterone) measured in the luteal phase, in 65 normally menstruating women post myocardial infarction (MI) and to investigate a possible relationship between the hormone profile and selected coronary artery disease (CAD) risk factors. The levels of gonadal hormones: estradiol, progesterone, follicle-stimulating hormone, luteinizing hormone, testosterone and dehydroepiandrosterone were measured in the luteal phase. All examined women had normal mean levels of gonadal hormones. In the post MI patients leading a sedentary life style, a significantly lower mean progesterone concentration was observed (16.29 ± 9.11 versus 29.43 ± 21.14 nmol/l, p < 0.05) and significantly higher mean testosterone concentration (2.34 ± 0.98 versus 1.76 ± 1.09 nmol/l, p < 0.05) when compared to patients from the same group, but leading a more active life. In obese post MI women (BMI ≥ 30 kg/m2) a lower mean concentration of progesterone was detected (18.02 ± 8.12 versus 26.16 ± 14.72 nmol/l, p < 0.05), than in slimmer patients from the same group. In post MI women with a positive family history for CAD, a significantly higher mean concentration of testosterone was detected (2.31 ± 1.22 versus 1.67 ± 0.74 nmol/l, p < 0.05) than in patients with no family history. The results suggest a correlation between levels of gonadal hormones and classical CAD risk factors.
Publisher

Year
Volume
58
Issue
3
Pages
385-389
Physical description
Dates
published
2011
received
2011-03-08
revised
2011-08-23
accepted
2011-09-02
(unknown)
2011-09-13
Contributors
  • Department of Acquired Heart Valve Diseases, National Institute of Cardiology, Warszawa, Poland
  • Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warszawa, Poland
author
  • Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warszawa, Poland
  • Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warszawa, Poland
  • Department of Acquired Heart Valve Diseases, National Institute of Cardiology, Warszawa, Poland
References
  • Adesuyi AL, Ajayi AAL, Mathur R, Halushka PV (1995) Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 91: 2742-2747.
  • Arciero TJ, Jacobsen SJ, Reeder GS, Frye RL, Weston SA, Killian JM, Roger Vr VL (2004) Temporal trends in the incidence of coronary disease. Am J Med 117: 228-233.
  • Berlin JA, Colditz GA (1990) A meta-analysis of physical activity in prevention of coronary heart disease. Am J Epidemiol 132: 612-628.
  • Binko J, Majewski H (1998) 17 β-estradiol reduces vasoconstriction in endothelium denuded rat aortas through inducible NOS. Am J Physiol 274: H853-H859.
  • Broda G (2000) The epidemiology of cardiovascular diseases in women. Kardiol Pol 52: III-6 (in Polish).
  • Caulin-Glaser T (1998) Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease. J Am Coll Cardiol 31: 1555-1559.
  • Dahlgren E, Janson PO, Johansson S, Lapidus L, Odén A (1992) Polycystic ovary syndrome and risk for myocardial infarction: evaluated from a risk factor model based on a prospective population study of women. Acta Obstet Gynecol Scand 71: 599-604.
  • Doughty M, Mehta R, Bruckman D, Das S, Karavite D, Tsai T, Eagle K (2002) Acute myocardial infarction in the young. The Univeristy of Michigan experience. Am Heart J 143: 56-62.
  • Ergin A, Muntner P, Sherwin R, He J (2004) Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States. Am J Med 117: 219-227.
  • Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE (2004) Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med 351: 2694-2703.
  • Klos J, Ceremuzyński L., Herbaczynska-Cedro K (2001) Lowered levels of gonadal hormones in women with premenopausal ischemic heart disease. Influence of cigarette smoking. Kardiol Pol 55: 305-307 (in Polish).
  • Klosiewicz-Wasek B, Ceremuzynski L, Polonski L, Lukaszewicz R, Wasilewski J (2008) Association between carotid artery atherosclerosis and coronary artery disease in young females. Reference to sex hormone profile. Kardiol Pol 66: 127-132; discussion 66: 133-134 (in Polish).
  • Lee TM, Su SF, Chou T, Tsai CH (2002) Pharmacological preconditioning of estrogen by activation of myocardial adenosine triphosphate-sensitive potassium channels in patients undergoing coronary angioplasty. J Am Coll Cardiol 39: 871-877.
  • Lee WS, Harder JA, Yoshizumi M, Lee ME, Haber E (1997) Progesterone inhibits arterial smooth muscle cell proliferation. Nat Med 3: 1005-1008.
  • Mauvais-Jarvis P (1983) Progesterone and progestins: a general overview. In Progesterone and Progestins. Bardin WC, Milgrom F, Mauvais-Jarvis P eds, p 1, Raven Press, New York.
  • Mc Crohon JA, Nakhla S, Jessup W, Stanley KK, Celermajer DS (1999) Estrogen and progesterone reduce lipid accumulation in human monocyte-derived macrophages. A sex-specific effect. Circulation 100: 2319-2325.
  • Mendelsohn ME, Karas RH (1999) The protective effects of estrogen on the cardiovascular system. N Engl J Med 340: 1801-1881.
  • Ostadal B, Netuka I, Maly J, Besik J, Ostadalova I (2009) Gender differences in cardiac ischemic injury and protection - experimental aspects. Exp Biol Med Maywood 234: 1011-1019.
  • Rosano GMC, Sarrel PM, Wilson PA, Collins P (1993) Beneficial effect of estrogen on exercise-induced myocardial ischaemia in women with coronary artery disease. Lancet 342: 133-136.
  • Seliger SL, Easterling TR, Gillen FL (2003) Platelet hyperreactivity in women from families with premature atherosclerosis. J Am Med Women's Assoc 58: 4 (abstract).
  • Smielak-Korombel W, Kulon I, Franaszek J, Kanas P (1986) Myocardial infarction in women to 45 years of age. Pol Tyg Lek 41: 1131-1133 (in Polish).
  • Talbott EO, Zborowski J, Reger J, Stragand IR (2008) Is there independent effect of polycystic ovary syndrome (PCOS) and menopause on the prevalence of subclinical atherosclerosis in middle aged women? Vasc Health Risk Manag 4: 453-462.
  • Tsun Ming L, Tai-Fwu T, Chanher T (2003) Differential role of K-ATP channels activated by conjugated estrogens in the regulation of myocardial and coronary protective effects. Circulation 107: 49-54.
  • Weksler B (2002) Hemostasis and thrombosis. In: Cardiovascular health and disease in women. 2nd edn, pp 157-177, Douglas PS ed, WB Saunders, Philadelphia.
  • Wenger NK (1998) Coronary heart disease in women. In: Textbook of women's health. Wallis LA, Kasper AS, Reader GG, Barbo DM, Brown W, Etingin OR, Nadelson CC, Pinn VW eds, pp 329-340, Lippincot-Raven Publishers, Philadelphia, New York.
  • WHO MONICA (1987) WHO MONICA Project: geographic variation in mortality from cardiovascular diseases. Baseline data on selected population characteristics and cardiovascular mortality. World Health Stat Q 40: 171-184.
  • Wranicz JK, Rosiak M, Cygankiewicz I, Kula P (2003) Sex steroids and heart variability in men with coronary artery disease after myocardial infarction. Pol Arch Med Wewn 109: 157-163 (in Polish).
  • Yusuf S, Hawken S, Rosengren S (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART Study): case-control study. Lancet 364: 937-952.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv58p385kz
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