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2011 | 58 | 3 | 381-384
Article title

Inulin supplementation in rat model of pouchitis

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EN
Abstracts
EN
Available data indicates potential effectiveness of prebiotic therapy in alleviating inflammation and prolonging the remission in inflammatory bowel disease. Documented successes of such therapies were the basis for this study. So far, there is no data related to the effectiveness of inulin application in symptomatic or severe pouchitis in humans or in animal model. The aim of the study was to determine the effect of inulin supplementation on the expression of intestinal inflammation and feeding efficiency in rats with induced pouchitis. Twenty-four Wistar rats were operated. After induction of pouchitis animals were randomly divided into control and supplementation groups receiving, respectively, semi-synthetic diet with or without inulin (in a lower (LD) or higher (HD) dose: 2.5 % or 5 % of total dietary content of mass) for a period of 6 weeks. Selected nutritional parameters were assessed throughout the study. Histopathological and immunohistochemical analysis of pouch mucosa specimens was also performed. The energy intake, weight gain, feeding efficiency, quality of stools were comparable in all studied groups. The intensity of inflammation (Moskovitz scale) and adaptive changes (Laumonier scale) did not differ between compared groups. The tissue expression of pro- and anti-inflammatory interleukins (IL-1α, IL-6, IL-10 and IL-12) was not different either. Inulin supplementation does not improve the quality of stools or the expression of intestinal inflammation in rats with induced pouchitis. It has no impact on the intensity of pouch adaptation or on feeding efficiency.
Publisher

Year
Volume
58
Issue
3
Pages
381-384
Physical description
Dates
published
2011
received
2011-03-05
revised
2011-07-11
accepted
2011-08-02
(unknown)
2011-08-29
Contributors
  • Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poznań, Poland
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
  • I Chair of Pediatrics, Department of Pediatric Gastroenterology and Metabolism, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Clinical Pathomorphology, Poznań University of Medical Sciences, Poznań, Poland
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
author
  • Chair of General Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland
  • Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poznań, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv58p381kz
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