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2011 | 58 | 3 | 313-319
Article title

Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats

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Abstracts
EN
Glucocorticoids and β2-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β2-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.
Year
Volume
58
Issue
3
Pages
313-319
Physical description
Dates
published
2011
received
2010-11-10
revised
2011-07-01
accepted
2011-08-19
(unknown)
2011-08-31
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv58p313kz
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