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2011 | 58 | 2 | 179-186
Article title

Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance

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EN
Abstracts
EN
This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with high-density lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.
Publisher

Year
Volume
58
Issue
2
Pages
179-186
Physical description
Dates
published
2011
received
2010-10-01
revised
2011-03-28
accepted
2011-05-03
(unknown)
2011-06-02
Contributors
  • UKM Medical Molecular Biology Institute (UMBI), University Kebangsaan, Malaysia
author
  • UKM Medical Molecular Biology Institute (UMBI), University Kebangsaan, Malaysia
author
  • Institute of Biological Sciences, University of Malaya, Malaysia
author
  • UKM Medical Molecular Biology Institute (UMBI), University Kebangsaan, Malaysia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv58p179kz
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