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2011 | 58 | 1 | 1-9
Article title

Prokaryotic toxin-antitoxin systems - the role in bacterial physiology and application in molecular biology

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Abstracts
EN
Bacteria have developed multiple complex mechanisms ensuring an adequate response to environmental changes. In this context, bacterial cell division and growth are subject to strict control to ensure metabolic balance and cell survival. A plethora of studies cast light on toxin-antitoxin (TA) systems as metabolism regulators acting in response to environmental stress conditions. Many of those studies suggest direct relations between the TA systems and the pathogenic potential or antibiotic resistance of relevant bacteria. Other studies point out that TA systems play a significant role in ensuring stability of mobile genetic material. The evolutionary origin and relations between various TA systems are still a subject of a debate. The impact of toxin-antitoxin systems on bacteria physiology prompted their application in molecular biology as tools allowing cloning of some hard-to-maintain genes, plasmid maintenance and production of recombinant proteins.
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Year
Volume
58
Issue
1
Pages
1-9
Physical description
Dates
published
2011
received
2010-03-16
revised
2011-01-24
accepted
2011-03-08
(unknown)
2011-03-11
Contributors
  • Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
author
  • Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
  • Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
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