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2010 | 57 | 1 | 95-97
Article title

Boric acid as a protector against paclitaxel genotoxicity

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EN
Abstracts
EN
Paclitaxel (PAC) is an anticancer drug used for treatments of breast, ovarian and lung cancers. However, little data is available in the literature on its potential genotoxicity on healthy human cells. On the other hand, boron deficiency and supplementation exert important biological effects in human and animal tissues. The biological effects of dietary boron are defined, but its interaction with PAC is not known for therapeutic uses. The aim of the present study was to determine whether boric acid (BA) confer a protection against PAC genotoxicity. After the application of PAC (10 or 20 µg/l) and BA (2.5 or 5 mg/l), the genotoxic effects were assessed by sister chromatid exchange (SCE) and micronucleus (MN) tests in human blood cultures. We also analyzed nuclear division index (NDI) in peripheral lymphocytes. Our results showed that PAC significantly (P<0.05) increased the frequencies of SCEs and the formations of MNs in peripheral lymphocytes as compared to controls. PAC decreased the nuclear division index in lymphocyte cultures. Boric acid did not show cytotoxic or genotoxic effects at the concentrations tested. Furthermore, the PAC-induced increases in the genotoxicity and cytotoxicity indices were diminished by the addition of BA. The present study suggests for the first time that BA can prevent the genotoxicity of PAC on human lymphocytes.
Publisher

Year
Volume
57
Issue
1
Pages
95-97
Physical description
Dates
published
2010
received
2009-11-14
revised
2010-01-04
accepted
2010-01-13
(unknown)
2010-03-19
Contributors
author
  • Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey
  • Department of Medical Genetics, Medical Faculty, Ataturk University, Erzurum, Turkey
  • Department of Pharmacology, Medical Faculty, Ataturk University, Erzurum, Turkey
author
  • Department of Medical Genetics, Medical Faculty, Ataturk University, Erzurum, Turkey
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv57p95kz
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