Adult-type hypolactasia and lactose malabsorption in Poland

• Authors: Edyta Mądry , Aleksandra Lisowska , Jarosław Kwiecień , Ryszard Marciniak , Anna Korzon-Burakowska , Sławomira Drzymała-Czyż , Ewa Mojs , Jarosław Walkowiak
• Languages of publication: EN

Abstracts

EN

Background: The available data on the incidence of lactose malabsorption are contradictory. Potential bias in random selection is a major drawback of studies performed to-date. Moreover, molecular analysis of polymorphism -13910 C>T upstream of the lactase (LCT) gene (NM_005915.4:c.1917+326C>T; rs4988235) has not been reported in those studies. Therefore, in this study we aimed to assess genetic predisposition and clinical manifestation of adult-type hypolactasia (ATH). Patients and methods: In two-hundred randomly chosen healthy subjects (HS) aged from 18 to 20 years, the presence of -13910 C>T polymorphic variants upstream of the LCT gene was assessed. In a subgroup of subjects with genotype predisposing to ATH, hydrogen-methane breath test (BT) with lactose loading was conducted to determine the current state of lactase activity. In addition, clinical symptoms typical for lactose malabsorption were assessed using the questionnaire method. Results: Sixty-three out of 200 (31.5 %) HS had -13910 C/C genotype. Thus, genetically determined lactase persistence is expected in the remaining 137 (68.5 %) subjects. Thirteen out of 53 (24.5 %) HS having -13910 C/C genotype were proved to be lactose intolerant. Recalculating the data for the entire studied population it implies the incidence of lactose malabsorption in 7.7 % of subjects. Only three out of 13 (23.1 %) subjects with abnormal BT results, reported clinical symptoms related to lactose consumption. Conclusions: Significantly lower than previously reported incidence of clinically detectable lactose malabsorption in young healthy adults in Poland has been documented. The -13910 C/C genotype upstream of the LCT gene indicates a predisposition to ATH, but definitely does not define the current ability to tolerate lactose.

Keywords

EN

lactose malabsorption; hypolactasia; genetic predisposition; lactose intolerance

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2010
• Volume: 57
• Issue: 4
• Pages: 585-588

Dates

published

2010

received

2010-08-02

revised

2010-10-20

accepted

2010-11-09

(unknown)

2010-12-10

Contributors

author

Edyta Mądry

• Department of Physiology, Poznań University of Medical Sciences, Poznań, Poland

author

Aleksandra Lisowska

• Department of Pediatric Gastroenterology & Metabolism, 1st Chair of Pediatrics

author

Jarosław Kwiecień

• Department of Pediatrics, The School of Medicine and Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

author

Ryszard Marciniak

• Chair of General, Gastroenterological and Endocrinological Surgery, Poznań University of Medical Sciences, Poznań, Poland

author

Anna Korzon-Burakowska

• Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland

author

Sławomira Drzymała-Czyż

• Department of Pediatric Gastroenterology & Metabolism, 1st Chair of Pediatrics

author

Ewa Mojs

• Clinical Psychology Department, Poznań University of Medical Sciences, Poznań, Poland

author

Jarosław Walkowiak

• Department of Pediatric Gastroenterology & Metabolism, 1st Chair of Pediatrics, Poznań, Poland

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