Normal levels of serum pancreatic enzymes in patients with progressive familial intrahepatic cholestasis type 2

• Authors: Jaroslaw Walkowiak , Irena Jankowska , Aleksandra Lisowska , Maciej Biczysko , Aldona Wierzbicka , Joanna Pawłowska
• Languages of publication: EN

Abstracts

EN

Introduction. High prevalence of elevated serum pancreatic enzymes in children with cholestasis with normal fecal elastase-1 concentrations has been documented. However, this state is related predominantly to biliary atresia. Therefore, we aimed to assess pancreatic damage by measuring serum pancreatic enzymes in patients with progressive familial intrahepatic cholestasis type 2 (PFIC type 2). Materials and methods. Twenty PFIC type 2 patients with normal serum bilirubin and bile acid concentrations were included in the study. Thirty pancreatic insufficient cystic fibrosis (PI-CF) patients, thirty patients with acute pancreatitis (AP) and thirty healthy subjects (HS) served for the purpose of comparison. In all subjects, serum lipase and elastase-1 levels were measured. Results. In all but one PFIC type 2 patients and all HS normal lipase activities were found. Serum elastase-1 concentrations were normal in all PFIC type 2 patients and HS. The enzyme levels were very similar in both groups studied. Lipase activities in PFIC type 2 patients were significantly higher than in PI-CF patients (p < 0.00001) and lower than in patients with AP (p < 0.00001). Serum elastase-1 levels in PFIC type 2 patients were significantly lower than in patients with AP (p < 0.00001) and not different from those in PI-CF patients. In conclusion. serum pancreatic enzymes in patients with PFIC type 2 are normal. No pancreatic damage in these patients could be detected.

Keywords

EN

pancreatitis; pancreatic enzymes; lipase; progressive familial intrahepatic cholestasis type 2; elastase-1

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2010
• Volume: 57
• Issue: 4
• Pages: 573-575

Dates

published

2010

received

2010-07-14

revised

2010-10-07

accepted

2010-11-03

(unknown)

2010-12-06

Contributors

author

Jaroslaw Walkowiak

• Poznań University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolism, Poznań, Poland

author

Irena Jankowska

• The Children's Memorial Health Institute, Department of Gastroenterology, Hepatology and Immunology, Warszawa, Poland

author

Aleksandra Lisowska

• Poznań University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolism, Poznań, Poland

author

Maciej Biczysko

• Poznań University of Medical Sciences, Chair of General, Gastroenterological and Endocrinological Surgery, Poznań, Poland

author

Aldona Wierzbicka

• The Children's Memorial Health Institute, Department of Biochemistry and Experimental Medicine, Warszawa, Poland

author

Joanna Pawłowska

• The Children's Memorial Health Institute, Department of Gastroenterology, Hepatology and Immunology, Warszawa, Poland

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