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2010 | 57 | 4 | 467-477
Article title

Homocysteine and vitamin therapy in stroke prevention and treatment: a review

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Abstracts
EN
Homocysteine (Hcy), a sulfur amino acid, is the only direct precursor for l-methionine synthesis through a reaction that requires vitamin B12, representing a connection with "one-carbon" units metabolism. Hcy catabolism requires vitamin B6 and as a consequence, alteration in folic acid and B vitamins status impairs Hcy biotransformation. Numerous studies have indicated that Hcy is an independent risk factor for cardio- and cerebrovascular diseases. In the last decade, several clinical trials have investigated the possible correlation between the use of folic acid and vitamins B6 and B12 for lowering Hcy plasma concentration and the reduced risk of stroke or its recurrence. This review is aimed to present some aspects of Hcy biochemistry, as well as the mechanisms through which it exerts the toxic effects on the vascular endothelium. We also discuss the results of some of the clinical trials developed to investigate the beneficial effects of vitamin therapy in the prevention and management of stroke.
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Year
Volume
57
Issue
4
Pages
467-477
Physical description
Dates
published
2010
received
2010-06-14
revised
2010-11-02
accepted
2010-11-28
(unknown)
2010-12-06
Contributors
  • Department of Biochemistry, School of Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania
author
  • Department of Organic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest, Romania
  • Department of Organic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest, Romania
  • Department of Rehabilitation and Physical Medicine, School of Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania
  • Department of Organic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest, Romania
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bwmeta1.element.bwnjournal-article-abpv57p467kz
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