"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats

• Authors: Fernanda M Ferreira , Francisco Peixoto , Elsa Nunes , Cristina Sena , Raquel Seiça , Maria Sancha Santos
• Languages of publication: EN

Abstracts

EN

Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.

Keywords

EN

oxidative phosphorylation; herbal medicine; Vaccinium myrtillus L.; Goto-Kakizaki (GK) rats; type 2 diabetes mellitus; Geranium robertianum L.

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2010
• Volume: 57
• Issue: 4
• Pages: 399-402

Dates

published

2010

received

2010-08-25

revised

2010-10-08

accepted

2010-10-22

(unknown)

2010-11-01

Contributors

author

Fernanda M Ferreira

• Department of Environment (CERNAS), Agricultural College of Coimbra - Polytechnic Institute of Coimbra, Bencanta, Coimbra, Portugal

author

Francisco Peixoto

• Chemistry Department (CECAV), University of Trás-os-Montes & Alto Douro, Vila Real, Portugal

author

Elsa Nunes

• Department of Physiology and Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

author

Cristina Sena

• Department of Physiology and Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

author

Raquel Seiça

• Department of Physiology and Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal

author

Maria Sancha Santos

• Department of Life Sciences, Center for Neurosciences and Cell Biology of Coimbra, Coimbra, Portugal

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