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2010 | 57 | 4 | 399-402
Article title

"MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats

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Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.
Physical description
  • Department of Environment (CERNAS), Agricultural College of Coimbra - Polytechnic Institute of Coimbra, Bencanta, Coimbra, Portugal
  • Chemistry Department (CECAV), University of Trás-os-Montes & Alto Douro, Vila Real, Portugal
  • Department of Physiology and Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Department of Physiology and Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Department of Physiology and Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Department of Life Sciences, Center for Neurosciences and Cell Biology of Coimbra, Coimbra, Portugal
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