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2010 | 57 | 3 | 261-264
Article title

Personal remarks on the future of protein crystallography and structural biology

Content
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Languages of publication
EN
Abstracts
EN
Protein crystallography, the main experimental method of structural biology, has undergone in the recent past three revolutionary changes leading to its unexpected renaissance. They were connected with (i) the introduction of synchrotron radiation sources for X-ray diffraction experiments, (ii) implementation of Se-Met multiwavelength anomalous diffraction (MAD) for phasing, and (iii) initiation of structural genomics (SG) programs. It can be foreseen that in the next 10-15 years protein crystallography will continue to be in this revolutionary phase. We can expect not only an avalanche of protein crystal structures from SG centers, but also attacking of more demanding projects, such as the structure of membrane proteins and of very large macromolecular complexes. On the technological front, the introduction of X-ray radiation from free-electron lasers will revolutionize the experimental possibilities, making feasible even the imaging of single molecules and of intact biological cells.
Publisher

Year
Volume
57
Issue
3
Pages
261-264
Physical description
Dates
published
2010
received
2010-07-09
revised
2010-07-20
accepted
2010-08-15
(unknown)
2010-08-19
Contributors
  • Department of Crystallography, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv57p261kz
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