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2010 | 57 | 1 | 23-34
Article title

Synthetic derivatives of genistein, their properties and possible applications

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EN
Abstracts
EN
Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.
Publisher

Year
Volume
57
Issue
1
Pages
23-34
Physical description
Dates
published
2010
received
2009-11-03
revised
2010-02-09
accepted
2010-03-02
(unknown)
2010-03-10
Contributors
  • Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
  • Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
  • Pharmaceutical Research Institute, Warszawa, Poland
  • Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
  • Silesian University of Technology, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Gliwice, Poland
  • Silesian University of Technology, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Gliwice, Poland
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Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv57p23kz
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