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2010 | 57 | 2 | 223-228
Article title

Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl

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Abstracts
EN
The aim of this study was to evaluate the therapeutic potential of oxidative stress (OS) reduction by using pyridoindole (PI) antioxidants in adjuvant arthritis (AA). The substances tested were stobadine dipalmitate (STB) and SMe1. AA was used as animal model. The experiments included healthy animals, control arthritic animals and arthritic animals with administration of PI in the oral daily dose of 15 mg/kg b.m during 28 experimental days. The rats were sacrificed on day 28. Clinical and biochemical parameters were determined. The effect of PI administration was evaluated on the basis of the following parameters: (a) arthritis (volume of hind paws - HPW, change of animal body mass - CBM), (b) OS (chemiluminescence of whole blood - CWB, levels of thiobarbituric acid reacting substance - TBARS and of HNE- and MDA-protein adducts in plasma and activity of γ-glutamyltransferase (GGT) in hind paw joint homogenates). The PI studied significantly increased the CBM of animals and corrected the HPW. STB also significantly decreased the activity of GGT in joint homogenates. SMe1 was more effective in decreasing plasmatic TBARS levels, but STB was more effective in reducing plasmatic HNE- and MDA-protein adducts. The assay for HNE- and MDA-adducts in plasma as a function of time was applied for the first time in AA. STB markedly decreased spontaneous and PMA-stimulated CWB and reduced neutrophil count. In summary, STB was more effective than SMe1 in reducing OS in AA. Our results showed that the reduction of OS in arthritis also corrected the clinical manifestations of the disease.
Year
Volume
57
Issue
2
Pages
223-228
Physical description
Dates
published
2010
received
2010-02-28
revised
2010-05-13
accepted
2010-06-09
(unknown)
2010-06-14
References
  • Aldini G, Dalle-Donne I, Facino RM, Milzani A, Carini M (2007) Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med Res Rev 27: 817-868.
  • Arnhold J, Sonntag K, Sauer H, Häntzschel H, Arnold K (1994) Increased native chemiluminescence in granulocytes isolated from synovial fluid and peripheral blood of patients with rheumatoid arthritis. J Biolumin Chemilumin 9: 79-86.
  • Baskol G, Demir H, Baskol M, Kilic E, Ates F, Kocer D, Muhtaroglu S (2005) Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis. Clin Biochem 38: 951-965.
  • Baskol G, Demir H, Baskol M, Kilic E, Ates F, Karakukcu C, Ustdal M (2006) Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis. Cell Biochem Funct 24: 307-311.
  • Bauerova K, Bezek A (1999) Role of reactive oxygen and nitrogen species in etiopathogenesis of rheumatoid arthritis. Gen Physiol Biophys 18: 15-20.
  • Bauerova K, Nosalova V, Mihalova D, Navarova J (2004) Contribution to safe anti-inflammatory therapy with indomethacin. Cent Eur J Public Health 12: S8-S10.
  • Bauerova K, Kucharska J, Mihalova D, Navarova J, Gvozdjakova A, Sumbalova Z (2005a) Effect of coenzyme Q10 supplementation in the rat model of adjuvant arthritis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149: 501-503.
  • Bauerova K, Valentova J, Ponist S, Navarova J, Komendova D, Mihalova D (2005b) Effect of copper complexes on the development of adjuvant arthritis: therapeutic and toxicological aspects. Biologia 60: 67-70.
  • Bauerova K, Ponist S, Ondrejickova O, Komendova D, Mihalova D (2006) Association between tissue gamma glutamyl-transferase and clinical markers of adjuvant arthritis in Lewis rats. Neuro Endocrinol Lett 27: 172-175.
  • Bauerova K, Kucharska J, Ponist S, Gvozdjakova A (2008a) Coenzyme Q10 supplementation in adjuvant arthritis (pre-clinical study). In Mitochondrial medicine: mitochodrial metabolism, diseases, diagnosis and therapy. Gvozdjakova A, eds, pp 340-342. Springer, Netherlands.
  • Bauerova K, Ponist S, Navarova J, Dubnickova M, Paulovicova E, Pajtinka M, Kogan G, Mihalova D (2008b) Glucomannan in prevention of oxidative stress and inflammation occuring in adjuvant arthritis. Neuro Endocrinol Lett 29: 691-696.
  • Bauerova K, Paulovicova E, Mihalova D, Svik K, Ponist S (2009) Study of new ways of supplementary and combinatory therapy of rheumatoid arthritis with immunomodulators. Glucomannan and imunoglukan in adjuvant arthritis. Toxicol Ind Health 25: 329-335.
  • Bezek S, Juranek I (2000) Effects of stobadine on hypoxia and hypoxia/reoxygenation injury in isolated hepatocytes from fasted rats. Biologia 55: 5-8.
  • Biasi F, Bosco M, Lanfranco G, Poli G (1995) Cytolysis does not per se induce lipid peroxidation: Evidence in man. Free Radic Biol Med 18: 909-912.
  • Bohanec Grabar P, Logar D, Tomsic M, Rozman B, Dolzan V (2009) Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients. Dis Markers 26: 41-48.
  • Brown RK, Kelly FJ (1996) Peroxides and other products. In: Free Radicals, a practical approach. Punchard NA, Kelly FJ, eds, pp 119-131. Oxford University Press, Oxford.
  • Carlisle ML, King MR, Karp DR (2003) gamma-Glutamyl transpeptidase activity alters the T cell response to oxidative stress and Fas-induced apoptosis. Int Immunol 15: 17-27.
  • Cedergren J, Forslund T, Sundqvist T, Skogh (2007) Intracellular oxidative activation in synovial fluid neutrophils from patients with rheumatoid arthritis but not from other arthritis patients. J Rheumatol 34: 2162-2170.
  • Cross A, Barnes T, Bucknall RC, Edwards SW, Moots RJ (2006) Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints. J Leukoc Biol 80: 521-528.
  • Dayer JM (2002) Interleukin 1 or tumor necrosis factor-alpha: which is the real target in rheumatoid arthritis? J Rheumatol (Suppl) 65: 10-15.
  • Drabikova K, Jancinova V, Nosal R, Pecivova J, Macickova T, Turcani P (2007) Inhibitory effect of stobadine on FMLP-induced chemiluminescence in human whole blood and isolated polymorphonuclear leukocytes. Luminescence 22: 67-71.
  • Drabikova K, Perecko T, Nosal R, Baureova K, Ponist S, Mihalova D, Kogan G, Jancinova V (2009) Glucomannan reduces neutrophil free radical production in vitro and in rats with adjuvant arthritis. Pharmacol Res 59: 399-403.
  • Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423: 356-361.
  • Gallova J, Szalayova S (2004) The effect of stobadine on the copper-induced peroxidation of egg yolk phosphatidylcholine in multilamellar liposomes. Gen Physiol Biophys 23: 297-306.
  • Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne I (2004) S-Glutathionylation: from redox regulation of protein functions to human diseases. J Cell Mol Med 8: 201-212.
  • Guz G, Demirogullari B, Ulusu NN, Dogu C, Demirtola A, Kavutcu M, Omeroglu S, Stefek M, Karasu Ç (2007) Stobadine protects rat kidney against ischaemia/reperfusion injury. Clin Exp Pharmacol Physiol 34: 210-216.
  • Gvozdjakova A, Kucharska J, Tanaka S, Neradova B, Bauerova K (2004) Coenzyme Q10 supplementation differently modulated heart and skeletal muscle mitochondrial function induced by adjuvant arthritis. Mitochondrion 4: 20-21.
  • He YH, Zhou J, Wang YS, Xiao C, Tong Y, Tang JC, Chan AS, Lu AP (2006) Anti-inflammatory and anti-oxidative effects of cherries on Freund's adjuvant-induced arthritis in rats. Scand J Rheumatol 35: 356-358.
  • Horakova L, Ondrejickova O, Bachrata K, Vajdova M (2000) Preventive effect of several antioxidants after oxidative stress on rat brain homogenates. Gen Physiol Biophys 19: 195-205.
  • Jancinova V, Perecko T, Nosal R, Kostalova D, Bauerova K, Drabikova K (2009) Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition. Eur J Pharmacol 612: 161-166.
  • Juranek I, Horakova L, Rackova L, Stefek M (2010) Antioxidants in treating pathologies involving oxidative damage: an update on medicinal chemistry and biological activity of stobadine and related pyridoindoles. Curr Med Chem 17: 552-570.
  • Kallay Z, Bittererova J, Brejcha A, Faberova V, Bezek S, Trnovec T (1990) Plasma concentration, tissue distribution and excretion of the prospective cardioprotective agent cis-(2)-2,3,4,4a,5,9b-hexahydro-2, 8-dimethyl-1H-pyrido-[4,3b] indole dihydrochloride in rats. Arzneimittelforschung 40: 974-979.
  • Kallay Z, Soltes L, Trnovec T (1991) Pharmacokinetics of stobadine and of the sum of its metabolites in rats during repeated administration. Biopharm Drug Dispos 12: 201-205.
  • Knezl V, Sotnikova R, Okruhlicova L, Navarova J (1999) Effect of stobadine on cardiac injury induced by ischemia and reperfusion. Life Sci 65: 1931-1933.
  • Kogan G, Stasko A, Bauerova K, Polovka M, Soltes L, Brezova V, Navarova J, Mihalova D (2005) Antioxidant properties of yeast (1-3)-β-D-glucan studied by electron paramagnetic resonance spectroscopy and its activity in the adjuvant arthritis. Carbohydr Polym 61: 18-28.
  • Koner BC, Banerjee BD, Ray A (1997) Effects of stress on gamma glutamyl transpeptidase (GGT) activity in lymphoid system of rats: modulation by drugs. Indian J Exp Biol 35: 222-224.
  • Kunsch C, Sikorski JA, Sundell CL (2005) Oxidative stress and the use of antioxidants for the treatment of rheumatoid arthritis. Curr Med Chem Immunol Endocr Metab Agents 5: 249-258.
  • Kurien BT, Hensley K, Bachmann M, Scofield RH (2006) Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 41: 549-56.
  • Miesel R, Hartung R, Kroeger H (1996) Priming of NADPH oxidase by tumor necrosis factor alpha in patients with inflammatory and autoimmune rheumatic diseases. Inflammation 20: 427-438.
  • Nosal R, Jancinova V, Petríkova M, Ponist S, Bauerova K (2007) Suppression of oxidative burst of neutrophils with methotrexate in rat adjuvant arthritis. Chem Listy 101: 243-244.
  • Ondrejickova O, Ziegelhoeffer A, Gabauer I, Sotnikova R, Styk J, Gibala P, Sedlak J, Horakova L (1993) Evaluation of ischemia-reperfusion injury by malondialdehyde, glutathione and gamma-glutamyl transpeptidase: lack of specific local effects in diverse parts of the dog heart following acute coronary occlusion. Cardioscience 4: 225-230.
  • Orlowski M, Meister A (1970) The γ-glutamyl cycle: a possible transport system for amino acids. Proc Natl Acad Sci USA 67: 1248-1255.
  • Poli G, Leonarduzzi G, Biasi F, Chiarpotto E (2004) Oxidative stress and cell signalling. Curr Med Chem 11: 1163-1182.
  • Requena JR, Fu MX, Ahmed MU, Jenkins AJ, Lyons TJ, Thorpe SR (1996) Lipoxidation products as biomarkers of oxidative damage to proteins during lipid peroxidation reactions. Nephrol Dial Transplant 11: 48-53.
  • Rambabu K, Ansari AA, Shaafie IA, Chelvam AP, Ziu MM (1990) Gamma-glutamyl transpeptidase in synovial fluid, serum, and urine of patients with rheumatoid arthritis. Biochem Med Metab Biol 43: 183-192.
  • Rovensky J, Stancikova M, Svik K, Bauerova K, Jurcovicova J (2009) The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis. Rheumatol Int doi: 10.1007/s00296-009-1258-z.
  • Sarban A, Kocyigit A, Yazar M, Isikan UE (2005) Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis. Clin Biochem 38: 981-986.
  • Sotnikova R, Ponist S, Navarova J, Mihalova D, Tomekova V, Strosova M, Bauerova K (2009) Effects of sesame oil in the model of adjuvant arthritis. Neuro Endocrinol Lett 30: 22-24.
  • Stolc S, Bauer V, Benes L, Tichy M (1983) Medicine with antiarrhythmic and antihypoxic activity and its method of preparation. Patents: CS 229 067, SWED. 8204693-9, BELG. 894148, SWISS 651 754, BRD P-3231088, SPAIN 553 017, JAP. 151 4040.
  • Strosova M, Tomaskova I, Ponist S, Bauerova K, Karlovska J, Spickett CM, Horakova L (2008) Oxidative impairment of plasma and skeletal muscle sarcoplasmic reticulum in rats with adjuvant arthritis - effects of pyridoindole antioxidants. Neuro Endocrinol Lett 29: 706-711.
  • Strosova M, Karlovska J, Spickett CM, Orszaghova Z, Ponist S, Bauerova K, Mihalova D, Horakova L (2009) Modulation of SERCA in the chronic phase of adjuvant arthritis as a possible adaptation mechanism of redox imbalance. Free Radic Res 43: 852-864.
  • Tastekin N, Aydogdu N, Dokmeci D, Usta U, Birtane M, Erbas H, Ture M (2007) Protective effects of l-carnitine and alpha-lipoic acid in rats with adjuvant arthritis. Pharmacol Res 56: 303-310.
  • Tsuchida M, Miura T, Mizutani K, Aibara K (1985) Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. Biochim Biophys Acta 834: 196-204.
  • Tuma DJ (2002) Role of malondialdehyde-acetaldehyde adducts in liver injury. Free Radic Biol Med. 32: 303-8.
  • Ulusu NN, Sahilli M, Avci A, Canbolat O, Ozansoy G, Ari N, Bali M, Stefek M, Stolc S, Gajdosik A, Karasu Ç (2003) Pentose phosphate pathway glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effect of stobadine and vitamin E. Neurochem Res 28: 815-823.
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Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv57p223kz
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