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2010 | 57 | 2 | 173-178
Article title

Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses

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Abstracts
EN
Bone regeneration is a process of vital importance since fractures of long bones and large joints have a highly deleterious impact on both, individuals and society. Numerous attempts have been undertaken to alleviate this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Since lipid peroxidation is an important component of systematic stress response in patients with traumatic brain injuries and bone fractures, studies have been undertaken of the molecular mechanisms of the involvement of 4-hydroxynonenal (HNE), an end product of lipid peroxidation, in cellular growth regulation. We found that HNE generated in bone cells grown in vitro on the surfaces of bioactive glasses 45S5 and 13-93. This raises an interesting possibility of combined action of HNE and ionic bioglass dissolution products in enhanced osteogenesis probably through a mitogen-activated protein kinase (MAPK) pathway. While the proposed mechanism still has to be elucidated, the finding of HNE generation on bioglass offers a new interpretation of the osteoinducting mechanisms of bioglass and suggests the possibility of tissue engineering based on manipulations of oxidative homeostasis.
Publisher

Year
Volume
57
Issue
2
Pages
173-178
Physical description
Dates
published
2010
received
2009-11-10
revised
2010-04-22
accepted
2010-05-14
(unknown)
2010-05-31
Contributors
  • Rudjer Boskovic Institute, Department of Molecular Medicine, Zagreb, Croatia
  • Medical University, LKH Clinic of Traumatology, Graz, Austria
  • Rudjer Boskovic Institute, Department of Molecular Medicine, Zagreb, Croatia
  • Department of Pathology, Medical Faculty, Clinical Hospital Centre, Zagreb, Croatia
author
  • Rudjer Boskovic Institute, Department of Molecular Medicine, Zagreb, Croatia
  • Rudjer Boskovic Institute, Department of Molecular Medicine, Zagreb, Croatia
author
  • Karl Franzens University, Institute of Molecular Biosciences, Graz, Austria
  • Rudjer Boskovic Institute, NMR Center, Zagreb, Croatia
  • Rudjer Boskovic Institute, Department of Molecular Medicine, Zagreb, Croatia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv57p173kz
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