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2009 | 56 | 4 | 679-685
Article title

Elevated advanced oxidation protein products levels in patients with liver cirrhosis

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EN
Abstracts
EN
Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.
Publisher

Year
Volume
56
Issue
4
Pages
679-685
Physical description
Dates
published
2009
received
2009-06-29
revised
2009-11-11
accepted
2009-11-26
(unknown)
2009-12-09
Contributors
  • Department of Pharmaceutical Biochemistry, Wrocław Medical University, Wrocław, Poland
  • Clinic of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wrocław Medical University, Wrocław, Poland
  • Clinic of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wrocław Medical University, Wrocław, Poland
author
  • Department of Pharmaceutical Biochemistry, Wrocław Medical University, Wrocław, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv56p679kz
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