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2009 | 56 | 4 | 655-662
Article title

5',8-Cyclo-2'-deoxyadenosine (cdA) formation by γ-radiation. Theoretical quantum mechanics study

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EN
Abstracts
EN
Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties. In the present study emphasis was put on the possible reaction modes of 2'-deoxyadenosine (dA) radicals, leading to the formation of related 5',8-cyclonucleosides. It appears that the prerequisite for the formation of 5',8-cyclo-2'-deoxyadenosine (cdA) is the adoption of O4'-exo conformation by 2-deoxyribose; however, this is the least energetically favored conformer among the different puckered forms adopted by the furanose ring. The O4'-exo conformation was found to be present in each of the discussed mechanisms.
Publisher

Year
Volume
56
Issue
4
Pages
655-662
Physical description
Dates
published
2009
received
2009-06-05
revised
2009-08-07
accepted
2009-10-05
(unknown)
2009-10-15
Contributors
  • Laboratoire des Lésions des Acides Nucléiques, INAC/SCIB-UMR-E n°3 CEA-UJF, CEA/Grenoble, Grenoble Cedex 9, France
author
  • Laboratoire des Lésions des Acides Nucléiques, INAC/SCIB-UMR-E n°3 CEA-UJF, CEA/Grenoble, Grenoble Cedex 9, France
author
  • Laboratoire des Lésions des Acides Nucléiques, INAC/SCIB-UMR-E n°3 CEA-UJF, CEA/Grenoble, Grenoble Cedex 9, France
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv56p655kz
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