Glutathione reductase activity correlates with concentration of extracellular matrix degradation products in synovial fluid from patients with joint diseases

• Authors: Krystyna Średzińska , Anna Galicka , Halina Porowska , Łukasz Średziński , Tadeusz Porowski , Janusz Popko
• Languages of publication: EN

Abstracts

EN

The mechanisms underlying cartilage matrix degradation in joint diseases is not fully understood but reactive oxygen species are implicated as main causative factors. Comparative studies of glutathione reductase (GR) activity in synovial fluid from patients with rheumatoid arthritis (RA), reactive arthritis (ReA) and osteoarthritis (OA) as well as correlations between GR activity and concentration of the major cartilage components in synovial fluid are presented in this study. We found significantly higher activity of GR in RA (about three-fold) and ReA (about two-fold) than in OA. In RA and ReA patients, GR activity in synovial fluid correlates negatively with the concentrations of collagen and degradation products of sulfated glycosaminoglycans. In OA patients the activity of GR was significantly lower than in RA and ReA, which positively correlated with the concentration of collagen and showed a tendency for positive correlation with the degradation products of sulfated glycosaminoglycans. Our results suggest that in RA and ReA patients increased activity of GR does not prevent the increased degradation of collagen and proteoglycans by ROS.

Keywords

EN

glutathione reductase; collagen; glycosaminoglycans; synovial fluid

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2009
• Volume: 56
• Issue: 4
• Pages: 635-640

Dates

published

2009

received

2009-06-01

revised

2009-10-01

accepted

2009-10-12

(unknown)

2009-10-22

Contributors

author

Krystyna Średzińska

• Department of Medical Chemistry, Medical University of Białystok, Białystok, Poland

author

Anna Galicka

• Department of Medical Chemistry, Medical University of Białystok, Białystok, Poland

author

Halina Porowska

• Department of Medical Chemistry, Medical University of Białystok, Białystok, Poland

author

Łukasz Średziński

• Students' Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland

author

Tadeusz Porowski

• Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland

author

Janusz Popko

• Department of Pediatric Orthopaedics and Traumatology, Medical University of Białystok, Białystok, Poland

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