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2009 | 56 | 4 | 635-640
Article title

Glutathione reductase activity correlates with concentration of extracellular matrix degradation products in synovial fluid from patients with joint diseases

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EN
Abstracts
EN
The mechanisms underlying cartilage matrix degradation in joint diseases is not fully understood but reactive oxygen species are implicated as main causative factors. Comparative studies of glutathione reductase (GR) activity in synovial fluid from patients with rheumatoid arthritis (RA), reactive arthritis (ReA) and osteoarthritis (OA) as well as correlations between GR activity and concentration of the major cartilage components in synovial fluid are presented in this study. We found significantly higher activity of GR in RA (about three-fold) and ReA (about two-fold) than in OA. In RA and ReA patients, GR activity in synovial fluid correlates negatively with the concentrations of collagen and degradation products of sulfated glycosaminoglycans. In OA patients the activity of GR was significantly lower than in RA and ReA, which positively correlated with the concentration of collagen and showed a tendency for positive correlation with the degradation products of sulfated glycosaminoglycans. Our results suggest that in RA and ReA patients increased activity of GR does not prevent the increased degradation of collagen and proteoglycans by ROS.
Publisher

Year
Volume
56
Issue
4
Pages
635-640
Physical description
Dates
published
2009
received
2009-06-01
revised
2009-10-01
accepted
2009-10-12
(unknown)
2009-10-22
Contributors
  • Department of Medical Chemistry, Medical University of Białystok, Białystok, Poland
author
  • Department of Medical Chemistry, Medical University of Białystok, Białystok, Poland
  • Department of Medical Chemistry, Medical University of Białystok, Białystok, Poland
  • Students' Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland
  • Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland
author
  • Department of Pediatric Orthopaedics and Traumatology, Medical University of Białystok, Białystok, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv56p635kz
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