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2009 | 56 | 4 | 597-612
Article title

Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity

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Abstracts
EN
Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.
Publisher

Year
Volume
56
Issue
4
Pages
597-612
Physical description
Dates
published
2009
received
2009-11-22
revised
2009-12-07
accepted
2009-12-10
(unknown)
2009-12-11
Contributors
author
  • Department of Molecular Biology, University of Gdańsk, Gdańsk, Poland
  • Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
  • Department of Molecular Biology, University of Gdańsk, Gdańsk, Poland
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