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2009 | 56 | 2 | 317-324
Article title

Unexpected domain composition of MACC1 links MET signaling and apoptosis

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EN
Abstracts
EN
Colorectal cancer, one of the most challenging malignancies, still has a limited number of recognized prognostic and predictive markers indicating appropriate treatment. MACC1 (metastasis-associated in colon cancer-1), a novel regulator of tumor growth and metastasis has recently been identified as an important prognostic factor of metastatic disease in colorectal cancer. The mechanism of MACC1 activity remains undetermined. Here we apply a combination of fold recognition and homology modeling algorithms to draft MACC1 function. The applied methods revealed that the MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Previously a similar domain architecture (ZU5-DD) was observed in other proteins, involved mainly in signal transduction and apoptosis regulation. Based on the specific aspects of the closest homologues' biology functional hypotheses on MACC1 are proposed. A broad range of bioinformatic analyzes indicates that MACC1, besides its involvement in signal transduction from the MET receptor, links MET signaling and apoptosis.
Publisher

Year
Volume
56
Issue
2
Pages
317-324
Physical description
Dates
published
2009
received
2009-04-02
revised
2009-05-06
accepted
2009-05-27
(unknown)
2009-06-04
Contributors
  • Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
  • Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
  • BioInfoBank Institute, Poznań, Poland
  • Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv56p317kz
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