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2008 | 55 | 4 | 749-752
Article title

Identification of 2-[2-nitro-4-(trifluoromethyl)benzoyl]- cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of 1H and 19F NMR spectroscopy

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Abstracts
EN
Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by 1H and 19F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as well as a few other unidentified compounds containing CF3 group was documented.
Keywords
Publisher

Year
Volume
55
Issue
4
Pages
749-752
Physical description
Dates
published
2008
received
2008-07-07
revised
2008-10-14
accepted
2008-11-21
(unknown)
2008-11-28
Contributors
  • Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland
  • Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland
  • Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland
  • Department of Biochemistry and Experimental Medicine, Children's Memorial Health Institute, Warszawa, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p749kz
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