PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 55 | 1 | 67-74
Article title

Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein

Content
Title variants
Languages of publication
EN
Abstracts
EN
The cytomegalovirus (CMV) genome encodes four clusters of genes expressed immediately after infection - i.e.: UL36-38, UL122-123, TRS1-IRS1, and US3. The general function of these genes is associated with inhibition of cellular mechanisms of antiviral response. Although several biological processes have been mapped onto specific gene products, the knowledge of the molecular mechanism of their activity remains fragmentary. Here, we report the application of protein structure prediction methods in assigning the function to a glycosylated domain encoded by UL37 of CMV (gpUL37, UL37x3). The discerned similarity clearly points out that this domain represents a novel type of a major histocompatibility complex (MHC)-like protein, and consequently may play a central role in an additional mechanism of escape from antiviral response.
Publisher

Year
Volume
55
Issue
1
Pages
67-74
Physical description
Dates
published
2008
received
2007-12-15
revised
2008-02-12
accepted
2008-02-26
(unknown)
2008-03-04
Contributors
  • Department of Gastroenterology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
  • BioInfoBank Institute, Poznań, Poland
References
  • Altschul S, Madden T, Schäffer A, Zhang J, Zhang Z, Miller W, Lipman D (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
  • Andoniou CE, Degli-Esposti MA (2006) Insights into the mechanisms of CMV-mediated interference with cellular apoptosis. Immunol Cell Biol 84: 99-106.
  • Arnoult D, Bartle LM, Skaletskaya A, Poncet D, Zamzami N, Park PU, Sharpe J, Youle RJ, Goldmacher VS (2004) Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci USA 101: 7988-7993.
  • Beck S, Barrell BG (1988) Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature 331: 269-272.
  • Bujnicki J, Elofsson A, Fischer D, Rychlewski L (2001) Structure prediction meta server. Bioinformatics 17: 750-751.
  • Colberg-Poley AM (1996) Functional roles of immediate early proteins encoded by the human cytomegalovirus UL36-38, UL115-119, TRS1/IRS1 and US3 loci. Intervirology 39: 350-360.
  • Colberg-Poley AM, Patel MB, Erezo DP, Slater JE (2000) Human cytomegalovirus UL37 immediate-early regulatory proteins traffic through the secretory apparatus and to mitochondria. J Gen Virol 81: 1779-1789.
  • Dolan A, Cunningham C, Hector RD, Hassan-Walker AF, Lee L, Addison C, Dargan DJ, McGeoch DJ, Gatherer D, Emery VC, Griffiths PD, Sinzger C, McSharry BP, Wilkinson GW, Davison AJ (2004) Genetic content of wild-type human cytomegalovirus. J Gen Virol 85: 1301-1312.
  • Eisenberg D, Luthy R, Bowie JU (1997) VERIFY3D: assessment of protein models with three-dimensional profiles. Methods Enzymol 277: 396-404.
  • Fischer D (2003) 3D-SHOTGUN: a novel, cooperative, fold-recognition meta-predictor. Proteins 51: 434-441.
  • Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC (1996) Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384: 134-141.
  • Ginalski K, Elofsson A, Fischer D, Rychlewski L (2003) 3D-Jury: a simple approach to improve protein structure predictions. Bioinformatics 19: 1015-1018.
  • Ginalski K, von Grotthuss M, Grishin N, Rychlewski L (2004) Detecting distant homology with Meta-BASIC. Nucleic Acids Res 32: W576-W581.
  • Goldmacher VS (2002) vMIA, a viral inhibitor of apoptosis targeting mitochondria. Biochimie 84: 177-185.
  • Gupta R, Brunak S (2002) Prediction of glycosylation across the human proteome and the correlation to protein function. Pac Symp Biocomput 310-322.
  • Hayajneh WA, Colberg-Poley AM, Skaletskaya A, Bartle LM, Lesperance MM, Contopoulos-Ioannidis DG, Kedersha NL, Goldmacher VS (2001a) The sequence and antiapoptotic functional domains of the human cytomegalovirus UL37 exon 1 immediate early protein are conserved in multiple primary strains. Virology 279: 233-240.
  • Hayajneh WA, Contopoulos-Ioannidis DG, Lesperance MM, Venegas AM, Colberg-Poley AM (2001b) The carboxyl terminus of the human cytomegalovirus UL37 immediate-early glycoprotein is conserved in primary strains and is important for transactivation. J Gen Virol 82: 1569-1579.
  • Holzerlandt R, Orengo C, Kellam P, Alba MM (2002) Identification of new herpesvirus gene homologs in the human genome. Genome Res 12: 1739-1748.
  • Jaroszewski L, Rychlewski L, Li Z, Li W, Godzik A (2005) FFAS03: a server for profile-profile sequence alignments. Nucleic Acids Res 33: W284-W288.
  • Johnson DC, Hegde NR (2002) Inhibition of the MHC class II antigen presentation pathway by human cytomegalovirus. Curr Top Microbiol Immunol 269: 101-115.
  • Jones DT (1999) Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol 292: 195-202.
  • Kelley L, MacCallum R, Sternberg M (2000) Enhanced genome annotation using structural profiles in the program 3D-PSSM. J Mol Biol 299: 499-520.
  • Kenneson A, Cannon MJ (2007) Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 17: 253-276.
  • Kluczyk A, Cebrat M, Zbozien-Pacamaj R, Lisowski M, Stefanowicz P, Wieczorek Z, Siemion IZ (2004) On the peptide-antipeptide interactions in interleukin-1 receptor system. Acta Biochim Polon 51: 57-66.
  • Knipe D, Howley P, Griffin D, Lamb R, Martin M, Roizman B, Straus S, eds. (2001) Fields Virology. Lippincott Williams & Wilkins, Philadelphia.
  • Lee M, Xiao J, Haghjoo E, Zhan X, Abenes G, Tuong T, Dunn W, Liu F (2000) Murine cytomegalovirus containing a mutation at open reading frame M37 is severely attenuated in growth and virulence in vivo. J Virol 74: 11099-11107.
  • Li W, Godzik A (2006) Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics 22: 1658-1659.
  • Linding R, Russell R, Neduva V, Gibson T (2003) GlobPlot: Exploring protein sequences for globularity and disorder. Nucleic Acids Res 31: 3701-3708.
  • Lopez-Botet M, Llano M, Ortega M (2001) Human cytomegalovirus and natural killer-mediated surveillance of HLA class I expression: a paradigm of host-pathogen adaptation. Immunol Rev 181: 193-202.
  • Maenaka K, Jones EY (1999) MHC superfamily structure and the immune system. Curr Opin Struct Biol 9: 745-753.
  • Mavinakere MS, Colberg-Poley AM (2004) Internal cleavage of the human cytomegalovirus UL37 immediate-early glycoprotein and divergent trafficking of its proteolytic fragments. J Gen Virol 85: 1989-1994.
  • McCormick AL, Smith VL, Chow D, Mocarski ES (2003) Disruption of mitochondrial networks by the human cytomegalovirus UL37 gene product viral mitochondrion-localized inhibitor of apoptosis. J Virol 77: 631-641.
  • Michelson S (2004) Consequences of human cytomegalovirus mimicry. Hum Immunol 65: 465-475.
  • Montague MG, Hutchison CA 3rd (2000) Gene content phylogeny of herpesviruses. Proc Natl Acad Sci USA 97: 5334-5339.
  • Natarajan K, Li H, Mariuzza RA, Margulies DH (1999) MHC class I molecules, structure and function. Rev Immunogenet 1: 32-46.
  • Patterson CE, Shenk T (1999) Human cytomegalovirus UL36 protein is dispensable for viral replication in cultured cells. J Virol 73: 7126-7131.
  • Pauleau AL, Larochette N, Giordanetto F, Scholz SR, Poncet D, Zamzami N, Goldmacher VS, Kroemer G (2007) Structure-function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA. Oncogene 26: 7067-7080.
  • Poncet D, Larochette N, Pauleau AL, Boya P, Jalil AA, Cartron PF, Vallette F, Schnebelen C, Bartle LM, Skaletskaya A, Boutolleau D, Martinou JC, Goldmacher VS, Kroemer G, Zamzami N (2004) An anti-apoptotic viral protein that recruits Bax to mitochondria. J Biol Chem 279: 22605-22614.
  • Poncet D, Pauleau AL, Szabadkai G, Vozza A, Scholz SR, Le Bras M, Briere JJ, Jalil A, Le Moigne R, Brenner C, Hahn G, Wittig I, Schagger H, Lemaire C, Bianchi K, Souquere S, Pierron G, Rustin P, Goldmacher VS, Rizzuto R, Palmieri F, Kroemer G (2006) Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA. J Cell Biol 174: 985-996.
  • Rost B, Sander C (1993) Improved prediction of protein secondary structure by use of sequence profiles and neural networks. Proc Natl Acad Sci USA 90: 7558-7562.
  • Sanchez R, Sali A (2000) Comparative protein structure modeling. Introduction and practical examples with modeller. Methods Mol Biol 143: 97-129.
  • Sinclair J, Sissons P (2006) Latency and reactivation of human cytomegalovirus. J Gen Virol 87: 1763-1779.
  • Sonnhammer EL, von Heijne G, Krogh A (1998) A hidden Markov model for predicting transmembrane helices in protein sequences. Proc Int Conf Intell Syst Mol Biol 6: 175-182.
  • Steininger C (2007) Clinical relevance of cytomegalovirus infection in patients with disorders of the immune system. Clin Microbiol Infect 13: 953-963.
  • Stenberg RM, Stinski MF (1985) Autoregulation of the human cytomegalovirus major immediate-early gene. J Virol 56: 676-682.
  • Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D (2007) Human cytomegalovirus UL38 protein blocks apoptosis. J Virol 81: 3109-3123.
  • Thompson J, Higgins D, Gibson T (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
  • Wagner CS, Walther-Jallow L, Buentke E, Ljunggren HG, Achour A, Chambers BJ (2008) Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells. J Leukoc Biol 83: 56-63.
  • Whitley RJ (1996). Herpesviruses In: Medical Microbiology. Galveston, The University of Texas Medical Branch at Galveston.
  • Wyrwicz LS, Rychlewski L (2007a) Fold recognition insights into function of herpes ICP4 protein. Acta Biochim Polon 54: 551-559.
  • Wyrwicz LS, Rychlewski L (2007b) Herpes glycoprotein gL is distantly related to chemokine receptor ligands. Antiviral Res 75: 83-86.
  • Wyrwicz LS, Rychlewski L (2007c) Identification of Herpes TATT-binding protein. Antiviral Res 75: 167-172.
  • Wyrwicz LS, Ginalski K, Rychlewski L (2008) HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein. Cell Cycle 7: 269-271.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p67kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.