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Article title

The role of Rsp5 ubiquitin ligase in regulation of diverse processes in yeast cells

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Rsp5 is a conserved ubiquitin ligase involved in regulation of numerous cellular processes. A growing number of publications describing new functions of the ligase have appeared in recent years. Rsp5 was shown to be involved in the control of intracellular trafficking of proteins via endocytosis and multivesicular body sorting. Moreover, nuclear functions of Rsp5 in response to various stresses have been discovered. Rsp5 is also involved in the regulation of unsaturated fatty acid and sterol synthesis and phospholipid composition. Here, an overview of Rsp5 functions with emphasis on its involvement in the regulation of lipid biosynthesis will be presented.
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  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
  • Agarwal AK, Rogers PD, Baerson SR, Jacob MR, Barker KS, Cleary JD, Walker LA, Nagle DG, Clark AM (2003) Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. J Biol Chem 278: 34998-35015.
  • Altheim BA, Schultz MC (1999) Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 96: 1345-1350.
  • Arnason T, Ellison MJ (1994) Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain. Mol Cell Biol 14: 7876-7883.
  • Arnason TG, Pisclevich MG, Dash MD, Davies GF, Harkness TA (2005) Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae. Eukaryot Cell 4: 134-146.
  • Ashby MN, Edwards PA (1990) Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase. J Biol Chem 265: 13157-13164.
  • Ashby MN, Kutsunai SY, Ackerman S, Tzagoloff A, Edwards PA (1992) COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase. J Biol Chem 267: 4128-4136.
  • Auld KL, Brown CR, Casolari JM, Komili S, Silver PA (2006) Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates. Mol Cell 21: 861-871.
  • Bagnat M, Keranen S, Shevchenko A, Simons K (2000) Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci USA 97: 3254-3259.
  • Bammert GF, Fostel JM (2000) Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. Antimicrob Agents Chemother 44: 1255-1265.
  • Beaudenon SL, Huacani MR, Wang G, McDonnell DP, Huibregtse JM (1999) Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol Cell Biol 19: 6972-6979.
  • Beck T, Schmidt A, Hall MN (1999) Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. J Cell Biol 146: 1227-1238.
  • Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB (2000) A novel pro-Arg motif recognized by WW domains. J Biol Chem 275: 10359-10369.
  • Bhattacharya S, Żołądek T, Haines DS (2008) WW domains 2 and 3 of Rsp5p play overlapping roles in binding to the LPKY motif of Spt23p and Mga2p. Int J Biochem Cell Biol 40: 147-157.
  • Bogdanov M, Sun J, Kaback HR, Dowhan W (1996) A phospholipid acts as a chaperone in assembly of a membrane transport protein. J Biol Chem 271: 11615-11618.
  • Bogdanov M, Umeda M, Dowhan W (1999) Phospholipid-assisted refolding of an integral membrane protein. Minimum structural features for phosphatidylethanolamine to act as a molecular chaperone. J Biol Chem 274: 12339-12345.
  • Bremer J, Greenberg DM (1960) Biosynthesis of choline in vitro. Biochim Biophys Acta 37: 173-175.
  • Carman GM, Henry SA (1989) Phospholipid biosynthesis in yeast. Annu Rev Biochem 58: 635-669.
  • Carman GM, Henry SA (1999) Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog Lipid Res 38: 361-399.
  • Carman GM, Han GS (2007) Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion. Biochim Biophys Acta 1771: 322-330.
  • Carratu L, Franceschelli S, Pardini CL, Kobayashi GS, Horvath I, Vigh L, Maresca B (1996) Membrane lipid perturbation modifies the set point of the temperature of heat shock response in yeast. Proc Natl Acad Sci USA 93: 3870-3875.
  • Carter JR, Kennedy EP (1966) Enzymatic synthesis of cytidine diphosphate diglyceride. J Lipid Res 7: 678-683.
  • Chang A, Cheang S, Espanel X, Sudol M (2000) Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNA polymerase II. J Biol Chem 275: 20562-20571.
  • Chavez S, Beilharz T, Rondon AG, Erdjument-Bromage H, Tempst P, Svejstrup JQ, Lithgow T, Aguilera A (2000) A protein complex containing Tho2 Hpr1 Mft1 and a novel protein Thp2 connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19: 5824-5834.
  • Cho W (2001) Membrane targeting by C1 and C2 domains. J Biol Chem 276: 32407-32410.
  • Choi JY, Stukey J, Hwang SY, Martin CE (1996) Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene. J Biol Chem 271: 3581-3589.
  • Chojnacki T, Dallner G (1988) The biological role of dolichol. Biochem J 251: 1-9.
  • Clancey CJ, Chang SC, Dowhan W (1993) Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant. J Biol Chem 268: 24580-24590.
  • Corey EJ, Matsuda SP, Bartel B (1994) Molecular cloning, characterization and overexpression of ERG7 the Saccharomyces cerevisiae gene encoding lanosterol synthase. Proc Natl Acad Sci USA 91: 2211-2215.
  • Czabany T, Athenstaedt K, Daum G (2007) Synthesis, storage and degradation of neutral lipids in yeast. Biochim Biophys Acta 1771: 299-309.
  • Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S (2000) Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants. Proc Natl Acad Sci USA 97: 6487-6492.
  • Daum G, Lees ND, Bard M, Dickson R (1998) Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14: 1471-1510.
  • de la Fuente N, Maldonado AM, Portillo F (1997) Yeast gene YOR137c is involved in the activation of the yeast plasma membrane H+-ATPase by glucose. FEBS Lett 420: 17-19.
  • Dean-Johnson M, Henry SA (1989) Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC and functional analysis of its structural gene the INO1 locus. J Biol Chem 264: 1274-1283.
  • Dihanich ME, Najarian D, Clark R, Gillman EC, Martin NC, Hopper AK (1987) Isolation and characterization of MOD5 a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae. Mol Cell Biol 7: 177-184.
  • Dimster-Denk D, Rine J, Phillips J, Scherer S, Cundiff P, DeBord K, Gilliland D, Hickman S, Jarvis A, Tong L, Ashby M (1999) Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix. J Lipid Res 40: 850-860.
  • Dowhan W (1997) Molecular basis for membrane phospholipid diversity: why are there so many lipids? Annu Rev Biochem 66: 199-232.
  • Dowhan W, Mileykovskaya E, Bogdanov M (2004) Diversity and versatility of lipid-protein interactions revealed by molecular genetic approaches. Biochim Biophys Acta 1666: 19-39.
  • Dunn R, Hicke L (2001) Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis. J Biol Chem 276: 25974-25981.
  • Dunn R, Klos DA, Adler AS, Hicke L (2004) The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo. J Cell Biol 165: 135-144.
  • Edwards PA, Tabor D, Kast HR, Venkateswaran A (2000) Regulation of gene expression by SREBP and SCAP. Biochim Biophys Acta 1529: 103-113.
  • Exton JH (1994) Messenger molecules derived from membrane lipids. Curr Opin Cell Biol 6: 226-229.
  • Fankhauser C, Homans SW, Thomas-Oates JE, McConville MJ, Desponds C, Conzelmann A, Ferguson MA (1993) Structures of glycosylphosphatidylinositol membrane anchors from Saccharomyces cerevisiae. J Biol Chem 268: 26365-26374.
  • Ferguson SB, Anderson ES, Harshaw RB, Thate T, Craig NL, Nelson HC (2005) Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics 169: 1203-1214.
  • Ferreira T, Regnacq M, Alimardani P, Moreau-Vauzelle C, Berges T (2004) Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion. Biochem J 378: 899-908.
  • Fisk HA, Yaffe MP (1999) A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J Cell Biol 145: 1199-1208.
  • Gajewska B, Kaminska J, Jesionowska A, Martin NC, Hopper AK, Żołądek T (2001) WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae. Genetics 157: 91-101.
  • Galan JM, Moreau V, Andre B, Volland C, Haguenauer-Tsapis R (1996) Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J Biol Chem 271: 10946-10952.
  • Gardner RG, Shearer AG, Hampton RY (2001) In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol 21: 4276-4291.
  • Gitan RS, Eide DJ (2000) Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter. Biochem J 346 Pt 2: 329-336.
  • Gonzalez CI, Martin CE (1996) Fatty acid-responsive control of mRNA stability. Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript. J Biol Chem 271: 25801-25809.
  • Grabinska K, Palamarczyk G (2002) Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. FEMS Yeast Res 2: 259-265.
  • Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D (2007) Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Mol Syst Biol 3: 116.
  • Gwizdek C, Hobeika M, Kus B, Ossareh-Nazari B, Dargemont C, Rodriguez MS (2005) The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation. J Biol Chem 280: 13401-13405.
  • Haitani Y, Takagi H (2008) Rsp5 is required for the nuclear export of mRNA of HSF1 and MSN2/4 under stress conditions in Saccharomyces cerevisiae. Genes Cells 13: 105-116.
  • Haitani Y, Shimoi H, Takagi H (2006) Rsp5 regulates expression of stress proteins via post-translational modification of Hsf1 and Msn4 in Saccharomyces cerevisiae. FEBS Lett 580: 3433-3438.
  • Hamilton KL, Butt AG (2000) The molecular basis of renal tubular transport disorders. Comp Biochem Physiol A Mol Integr Physiol 126: 305-321.
  • Harkness TA, Davies GF, Ramaswamy V, Arnason TG (2002) The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps. Genetics 162: 615-632.
  • Harvey KF, Kumar S (1999) Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. Trends Cell Biol 9: 166-169.
  • Hashikawa N, Sakurai H (2004) Phosphorylation of the yeast heat shock transcription factor is implicated in gene-specific activation dependent on the architecture of the heat shock element. Mol Cell Biol 24: 3648-3659.
  • Heese-Peck A, Pichler H, Zanolari B, Watanabe R, Daum G, Riezman H (2002) Multiple functions of sterols in yeast endocytosis. Mol Biol Cell 13: 2664-2680.
  • Hein C, André B (1997) A C-terminal di-leucine motif and nearby sequences are required for NH4+-induced inactivation and degradation of the general amino acid permease Gap1p of Saccharomyces cerevisiae. Mol Microbiol 24: 607-616.
  • Helliwell SB, Losko S, Kaiser CA (2001) Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J Cell Biol 153: 649-662.
  • Henry KW, Nickels JT, Edlind TD (2002) ROX1 and ERG regulation in Saccharomyces cerevisiae: implications for antifungal susceptibility. Eukaryot Cell 1: 1041-1044.
  • Herscovics A, Orlean P (1993) Glycoprotein biosynthesis in yeast. FASEB J 7: 540-550.
  • Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67: 425-479.
  • Hicke L (2001) Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol 2: 195-201.
  • Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30: 405-439.
  • Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S (2000) Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell 102: 577-586.
  • Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP (1999) Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science 286: 1321-1326.
  • Huibregtse JM, Scheffner M, Beaudenon S, Howley PM (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci USA 92: 5249.
  • H urley JH, Misra S (2000) Signaling and subcellular targeting by membrane-binding domains. Annu Rev Biophys Biomol Struct 29: 49-79.
  • Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, Mizushima N, Tanida I, Kominami E, Ohsumi M, Noda T, Ohsumi Y (2000) A ubiquitin-like system mediates protein lipidation. Nature 408: 488-492.
  • Ingham RJ, Gish G, Pawson T (2004) The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene 23: 1972-1984.
  • Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (2000) The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 10: 429-439.
  • Jahnke L, Klein HP (1983) Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae. J Bacteriol 155: 488-492.
  • Jennings SM, Tsay YH, Fisch TM, Robinson GW (1991) Molecular cloning and characterization of the yeast gene for squalene synthetase. Proc Natl Acad Sci USA 88: 6038-6042.
  • Kaliszewski P, Ferreira T, Gajewska B, Szkopinska A, Berges T, Żołądek T (2006) Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase. Biochem J 395: 173-181.
  • Kaliszewski P, Szkopinska A, Ferreira T, Swiezewska E, Berges T, Żołądek T (2008) Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1781: 627-634.
  • Kaminska J, Tobiasz A, Gniewosz M, Żołądek T (2000) The growth of mdp1/rsp5 mutants of Saccharomyces cerevisiae is affected by mutations in the ATP-binding domain of the plasma membrane H+-ATPase. Gene 242: 133-140.
  • Kaminska J, Grabinska K, Kwapisz M, Sikora J, Smagowicz WJ, Palamarczyk G, Żołądek T, Boguta M (2002) The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. FEMS Yeast Res 2: 31-37.
  • Kaminska J, Kwapisz M, Grabinska K, Orlowski J, Boguta M, Palamarczyk G, Żołądek T (2005) Rsp5 ubiquitin ligase affects isoprenoid pathway and cell wall organization in S. cerevisiae. Acta Biochim Polon 52: 207-220.
  • Kato M, Wickner W (2001) Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion. EMBO J 20: 4035-4040.
  • Katzmann DJ, Babst M, Emr SD (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex ESCRT-I. Cell 106: 145-155.
  • Katzmann DJ, Odorizzi G, Emr SD (2002) Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol 3: 893-905.
  • Katzmann DJ, Sarkar S, Chu T, Audhya A, Emr SD (2004) Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol Biol Cell 15: 468-480.
  • Kiyono K, Miura K, Kushima Y, Hikiji T, Fukushima M, Shibuya I, Ohta A (1987) Primary structure and product characterization of the Saccharomyces cerevisiae CHO1 gene that encodes phosphatidylserine synthase. J Biochem 102: 1089-1100.
  • Klig LS, Henry SA (1984) Isolation of the yeast INO1 gene: located on an autonomously replicating plasmid the gene is fully regulated. Proc Natl Acad Sci USA 81: 3816-3820.
  • Kornblatt JA, Rudney H (1971) Two forms of acetoacetyl coenzyme A thiolase in yeast. I Separation and properties. J Biol Chem 246: 4417-4423.
  • Kumar S, Tomooka Y, Noda M (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185: 1155-1161.
  • Kwapisz M, Cholbinski P, Hopper AK, Rousset JP, Żołądek T (2005) Rsp5 ubiquitin ligase modulates translation accuracy in yeast Saccharomyces cerevisiae. RNA 11: 1710-1718.
  • Kwast KE, Lai L-C, Menda N, James DT 3rd, Aref S, Burke PV (2002) Genomic analyses of anaerobically induced genes in Saccharomyces cerevisiae: functional roles of Rox1 and other factors in mediating the anoxic response. J Bacteriol 184: 250-265.
  • Lester RL, Dickson RC (1993) Sphingolipids with inositolphosphate-containing head groups. Adv Lipid Res 26: 253-274.
  • Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP (2002) Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. J Cell Biol 157: 417-427.
  • Lu PJ, Zhou XZ, Shen M, Lu KP (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283: 1325-1328.
  • Lu JY, Lin YY, Qian J, Tao SC, Zhu J, Pickart C, Zhu H (2008) Functional dissection of a HECT ubiquitin E3 ligase. Mol Cell Proteomics 7: 35-45.
  • Macias MJ, Hyvonen M, Baraldi E, Schultz J, Sudol M, Saraste M, Oschkinat H (1996) Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Nature 382: 646-649.
  • Medintz I, Jiang H, Michels CA (1998) The role of ubiquitin conjugation in glucose-induced proteolysis of Saccharomyces maltose permease. J Biol Chem 273: 34454-34462.
  • Morvan J, Froissard M, Haguenauer-Tsapis R, Urban-Grimal D (2004) The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies. Traffic 5: 383-392.
  • Munn AL, Heese-Peck A, Stevenson BJ, Pichler H, Riezman H (1999) Specific sterols required for the internalization step of endocytosis in yeast. Mol Biol Cell 10: 3943-3957.
  • Murray M, Greenberg ML (2000) Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol carbon source and growth stage and is decreased by lithium and valproate. Mol Microbiol 36: 651-661.
  • Nakagawa Y, Sakumoto N, Kaneko Y, Harashima S (2002) Mga2p is a putative sensor for low temperature and oxygen to induce OLE1 transcription in Saccharomyces cerevisiae. Biochem Biophys Res Commun 291: 707-713.
  • Nalefski EA, Falke JJ (1996) The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci 5: 2375-2390.
  • Neumann S, Petfalski E, Brugger B, Grosshans H, Wieland F, Tollervey D, Hurt E (2003) Formation and nuclear export of tRNA rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p. EMBO Rep 4: 1156-1162.
  • Nikawa J, Yamashita S (1984) Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae. Eur J Biochem 143: 251-256.
  • Nikawa J, Tsukagoshi Y, Kodaki T, Yamashita S (1987) Nucleotide sequence and characterization of the yeast PSS gene encoding phosphatidylserine synthase. Eur J Biochem 167: 7-12.
  • Ntambi JM (1999) Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 40: 1549-1558.
  • Oelkers P, Tinkelenberg A, Erdeniz N, Cromley D, Billheimer JT, St urley SL (2000) A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast. J Biol Chem 275: 15609-15612.
  • Oelkers P, Cromley D, Padamsee M, Billheimer JT, St urley SL (2002) The DGA1 gene determines a second triglyceride synthetic pathway in yeast. J Biol Chem 277: 8877-8881.
  • Parks LW, Casey WM (1995) Physiological implications of sterol biosynthesis in yeast. Annu Rev Microbiol 49: 95-116.
  • Paulus H, Kennedy EP (1960) The enzymatic synthesis of inositol monophosphatide. J Biol Chem 235: 1303-1311.
  • Piper RC, Katzmann DJ (2007) Biogenesis and function of multivesicular bodies. Annu Rev Cell Dev Biol 23: 519-547.
  • Pizzirusso M, Chang A (2004) Ubiquitin-mediated targeting of a mutant plasma membrane ATPase Pma1-7 to the endosomal/vacuolar system in yeast. Mol Biol Cell 15: 2401-2409.
  • Raiborg C, Rusten TE, Stenmark H (2003) Protein sorting into multivesicular endosomes. Curr Opin Cell Biol 15: 446-455.
  • Rattray JB, Schibeci A, Kidby DK (1975) Lipids of yeasts. Bacteriol Rev 39: 197-231.
  • Reggiori F, Pelham HR (2001) Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J 20: 5176-5186.
  • Reid J, Svejstrup JQ (2004) DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. J Biol Chem 279: 29875-29878.
  • Rodriguez RJ, Parks LW (1983) Structural and physiological features of sterols necessary to satisfy bulk membrane and sparking requirements in yeast sterol auxotrophs. Arch Biochem Biophys 225: 861-871.
  • Rodriguez MS, Gwizdek C, Haguenauer-Tsapis R, Dargemont C (2003) The HECT ubiquitin ligase Rsp5p is required for proper nuclear export of mRNA in Saccharomyces cerevisiae. Traffic 4: 566-575.
  • Rotin D, Staub O, Haguenauer-Tsapis R (2000) Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases. J Membr Biol 176: 1-17.
  • Sagami H, Igarashi Y, Tateyama S, Ogura K, Roos J, Lennarz WJ (1996) Enzymatic formation of dehydrodolichal and dolichal, new products related to yeast dolichol biosynthesis. J Biol Chem 271: 9560-9566.
  • Sagami H, Korenaga T, Ogura K (1993) Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J Biochem 114: 118-121.
  • Sandager L, Gustavsson MH, Stahl U, Dahlqvist A, Wiberg E, Banas A, Lenman M, Ronne H, Stymne S (2002) Storage lipid synthesis is non-essential in yeast. J Biol Chem 277: 6478-6482.
  • Sato R, Inoue J, Kawabe Y, Kodama T, Takano T, Maeda M (1996) Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. J Biol Chem 271: 26461-26464.
  • Sato M, Fujisaki S, Sato K, Nishimura Y, Nakano A (2001) Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis. Genes Cells 6: 495-506.
  • Schneiter R, Kohlwein SD (1997) Organelle structure, function and inheritance in yeast: a role for fatty acid synthesis? Cell 88: 431-434.
  • Segura-Morales C, Pescia C, Chatellard-Causse C, Sadoul R, Bertrand E, Basyuk E (2005) Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding. J Biol Chem 280: 27004-27012.
  • Shcherbik N, Żołądek T, Nickels JT, Haines DS (2003) Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Curr Biol 13: 1227-1233.
  • Shcherbik N, Kee Y, Lyon N, Huibregtse JM, Haines DS (2004) A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p. J Biol Chem 279: 53892-53898.
  • Shearwin-Whyatt L, Dalton HE, Foot N, Kumar S (2006) Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays 28: 617-628.
  • Shen H, Dowhan W (1996) Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae. J Biol Chem 271: 29043-29048.
  • Shi Z, Buntel CJ, Griffin JH (1994) Isolation and characterization of the gene encoding 23-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Proc Natl Acad Sci USA 91: 7370-7374.
  • Somesh BP, Sigurdsson S, Saeki H, Erdjument-Bromage H, Tempst P, Svejstrup JQ (2007) Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD. Cell 129: 57-68.
  • Song L, Poulter CD (1994) Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II. Proc Natl Acad Sci USA 91: 3044-3048.
  • Sorger D, Daum G (2002). Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae. J Bacteriol 184: 519-524.
  • Sorger D, Daum G (2003) Triacylglycerol biosynthesis in yeast. Appl Microbiol Biotechnol 61: 289-299.
  • Sorger D, Athenstaedt K, Hrastnik C, Daum G (2004) A yeast strain lacking lipid particles bears a defect in ergosterol formation. J Biol Chem 279: 31190-31196.
  • Springael JY, De Craene JO, Andre B (1999a) The yeast Npi1/Rsp5 ubiquitin ligase lacking its N-terminal C2 domain is competent for ubiquitination but not for subsequent endocytosis of the gap1 permease. Biochem Biophys Res Commun 257: 561-566.
  • Springael JY, Galan JM, Haguenauer-Tsapis R, Andre B (1999b) NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains. J Cell Sci 112: 1375-1383.
  • Stawiecka-Mirota M, Pokrzywa W, Morvan J, Żołądek T, Haguenauer-Tsapis R, Urban-Grimal D, Morsomme P (2007) Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation. Traffic 8: 1280-1296.
  • Stewart LC, Yaffe MP (1991) A role for unsaturated fatty acids in mitochondrial movement and inheritance. J Cell Biol 115: 1249-1257.
  • Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417: 304-308.
  • Stukey JE, McDonough VM, Martin CE (1989) Isolation and characterization of OLE1 a gene affecting fatty acid desaturation from Saccharomyces cerevisiae. J Biol Chem 264: 16537-16544.
  • Sudol M (1996) Structure and function of the WW domain. Prog Biophys Mol Biol 65: 113-132.
  • Sullivan JA, Lewis MJ, Nikko E, Pelham HR (2007) Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro. Mol Biol Cell 18: 2429-2440.
  • Trotter PJ, Voelker DR (1995) Identification of a non-mitochondrial phosphatidylserine decarboxylase activity (PSD2) in the yeast Saccharomyces cerevisiae. J Biol Chem 270: 6062-6070.
  • Turunen M, Olsson J, Dallner G (2004) Metabolism and function of coenzyme Q. Biochim Biophys Acta 1660: 171-199.
  • Umebayashi K, Nakano A (2003) Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. J Cell Biol 161: 1117-1131.
  • Urbanowski JL, Piper RC (2001) Ubiquitin sorts proteins into the intralumenal degradative compartment of the late-endosome/vacuole. Traffic 2: 622-630.
  • Vasconcelles MJ, Jiang Y, McDaid K, Gilooly L, Wretzel S, Porter DL, Martin CE, Goldberg MA (2001) Identification and characterization of a low oxygen response element involved in the hypoxic induction of a family of Saccharomyces cerevisiae genes. Implications for the conservation of oxygen sensing in eukaryotes. J Biol Chem 276: 14374-14384.
  • Vik A, Rine J (2001) Upc2p and Ecm22p dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol 21: 6395-6405.
  • Wang G, Yang J, Huibregtse JM (1999) Functional domains of the Rsp5 ubiquitin-protein ligase. Mol Cell Biol 19: 342-352.
  • Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-139.
  • Weissman AM (2001) Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2: 169-178.
  • Welihinda AA, Beavis AD, Trumbly RJ (1994) Mutations in LIS1 (ERG6) gene confer increased sodium and lithium uptake in Saccharomyces cerevisiae. Biochim Biophys Acta 1193: 107-117.
  • Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl TM, Rothstein R, St urley SL (1996) Sterol esterification in yeast: a two-gene process. Science 272: 1353-1356.
  • Yu C, Kennedy NJ, Chang CC, Rothblatt JA (1996) Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA : sterol acyltransferase. J Biol Chem 271: 24157-24163.
  • Zenklusen D, Vinciguerra P, Wyss JC, Stutz F (2002) Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol 22: 8241-8253.
  • Zhang S, Skalsky Y, Garfinkel DJ (1999) MGA2 or SPT23 is required for transcription of the Δ9 fatty acid desaturase gene, OLE1 and nuclear membrane integrity in Saccharomyces cerevisiae. Genetics 151: 473-483.
  • Żołądek T, Vaduva G, Hunter LA, Boguta M, Go BD, Martin NC, Hopper AK (1995) Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3' ends and/or protein synthesis in mitochondrial delivery. Mol Cell Biol 15: 6884-6894.
  • Żołądek T, Tobiasz A, Vaduva G, Boguta M, Martin NC, Hopper AK (1997) MDP1 a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution is identical to the ubiquitin-protein ligase gene RSP5. Genetics 145: 595-603.
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