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2008 | 55 | 3 | 613-617
Article title

Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

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The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
Physical description
  • Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Chair of Applied Pharmacy, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
  • Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
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