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2008 | 55 | 3 | 587-594
Article title

Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis

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Abstracts
EN
The aim was to investigate different genotypes and haplotypes of methylenetetrahydrofolate reductase (MTHFR-677, -1298) and plasma concentration of total homocysteine (tHcy) in Macedonian patients with occlusive artery disease (OAD) and deep venous thrombosis (DVT). Investigated groups consists of 80 healthy, 74 patients with OAD, and 63 patients with DVT. Plasma tHcy was measured with Microplate Enzyme Immunoassay. Identification of MTHFR genotypes and haplotypes was done with CVD StripAssay. The probability level (P-value) was evaluated by the Student's t-test. Plasma concentration of tHcy in CC and CT genotypes of MTHFR C677T was significantly increased in patients with OAD and in patients with DVT. Plasma concentration of tHcy in AC genotype of MTHFR A1298C was increased in patients with OAD and in patients with DVT. Plasma concentration of tHcy was significantly increased in AA genotype of patients with OAD, but not in patients with DVT. We found a significant increase of plasma tHcy in patients with OAD in comparison with healthy respondents for normal:heterozygote (CC:AC), heterozygote:normal (CT:AA), and heterozygote:heterozygote (CT:AC) haplotypes. Plasma concentration of tHcy in patients with DVT in comparison with healthy respondents was significantly increased for normal:normal (CC:AA), normal heterozygote (CC:AC), and heterozygote:heterozygote (CT:AC) haplotypes. We conclude that MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with OAD and DVT.
Publisher

Year
Volume
55
Issue
3
Pages
587-594
Physical description
Dates
published
2008
received
2008-06-26
revised
2008-09-12
accepted
2008-09-16
(unknown)
2008-09-18
Contributors
author
  • Clinic for Cardiology, Faculty of Medicine, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
author
  • Clinic for Cardiology, Faculty of Medicine, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Clinic for Cardiology, Faculty of Medicine, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
author
  • Institute of Immunobiology and Human Genetics, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Medical and Experimental Biochemistry, Faculty of Medicine, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Medical and Experimental Biochemistry, Faculty of Medicine, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Medical and Experimental Biochemistry, Faculty of Medicine, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Transfusion, Skopje, Republic of Macedonia
author
  • Institute of Immunobiology and Human Genetics, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Immunobiology and Human Genetics, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
author
  • Institute of Immunobiology and Human Genetics, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Immunobiology and Human Genetics, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
  • Institute of Immunobiology and Human Genetics, University "Ss. Kiril and Metodij", Skopje, Republic of Macedonia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p587kz
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