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2008 | 55 | 3 | 581-585
Article title

Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus

Content
Title variants
Languages of publication
EN
Abstracts
EN
Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.
Publisher

Year
Volume
55
Issue
3
Pages
581-585
Physical description
Dates
published
2008
received
2008-05-25
revised
2008-08-10
accepted
2008-08-18
(unknown)
2008-08-25
Contributors
author
  • Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
  • Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
  • Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Gdańsk, Poland
  • Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p581kz
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