Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells

• Authors: Jingchun Yang , Qiang Li , Huirong Yang , Lichong Yan , Liu Yang , Long Yu
• Languages of publication: EN

Abstracts

EN

Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.

Keywords

EN

copper toxicity; CUTA isoform2; overexpression; copper-induced apoptosis; cell proliferation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2008
• Volume: 55
• Issue: 2
• Pages: 411-415

Dates

published

2008

received

2008-01-31

revised

2008-05-13

accepted

2008-06-11

(unknown)

2008-06-14

Contributors

author

Jingchun Yang

• State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China

author

Qiang Li

• State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China

author

Huirong Yang

• State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China

author

Lichong Yan

• School of Life Science, Soochow University, Soochow, P. R. China

author

Liu Yang

• State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China

author

Long Yu

• State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China

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